4-Chloro-2,2,6,6-tetramethylpiperidine

Base Information

• Chemical Name: 4-Chloro-2,2,6,6-tetramethylpiperidine
• CAS No.: 1463-00-9
• Molecular Formula: C9H18ClN
• Molecular Weight: 175.702
• DSSTox Substance ID: DTXSID50381659
• Wikidata: Q82172624
• Mol file: 1463-00-9.mol

Synonyms:4-chloro-2,2,6,6-tetramethylpiperidine;1463-00-9;Piperidine, 4-chloro-2,2,6,6-tetramethyl-;SCHEMBL2255646;DTXSID50381659;AT35805;CS-0530048

Chemical Property of 4-Chloro-2,2,6,6-tetramethylpiperidine

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 175.1127773
• Heavy Atom Count: 11
• Complexity: 136

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CC(CC(N1)(C)C)Cl)C

Technology Process of 4-Chloro-2,2,6,6-tetramethylpiperidine

There total 3 articles about 4-Chloro-2,2,6,6-tetramethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE (36768-62-4) → 1,2,3,6-tetrahydro-2,2,6,6-tetramethylpyridine (1124-69-2) + 4-chloro-2,2,6,6-tetramethylpiperidine (1463-00-9)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; pH=3 - 5;

DOI:10.1023/A:1019597921100

Reference yield: 26.0%

4-chloro-2,2,6,6-tetramethylpiperidine-1-oxyl (3225-24-9) → 4-chloro-2,2,6,6-tetramethylpiperidine (1463-00-9) + 4-Chloro-1-ethanesulfonyl-2,2,6,6-tetramethyl-piperidine (131309-39-2)

Guidance literature:

With ethanethiol; In benzene; Yields of byproduct given;

DOI:10.1007/BF00808373

Reference yield:

4-chloro-2,2,6,6-tetramethylpiperidine-1-oxyl (3225-24-9) + ethanethiol (75-08-1) → Diethyl disulfide (110-81-6) + 4-chloro-2,2,6,6-tetramethylpiperidine (1463-00-9) + 4-Chloro-1-ethanesulfonyl-2,2,6,6-tetramethyl-piperidine (131309-39-2)

Guidance literature:

In benzene;

DOI:10.1007/BF00808373

upstream raw materials:

4-chloro-2,2,6,6-tetramethylpiperidine-1-oxyl

ethanethiol

4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE