N-[(3S)-2-oxopyrrolidin-3-yl]formamide

Base Information

• Chemical Name: N-[(3S)-2-oxopyrrolidin-3-yl]formamide
• CAS No.: 146679-04-1
• Molecular Formula: C₅H₈N₂O₂
• Molecular Weight: 128.131
• European Community (EC) Number: 864-300-0
• Nikkaji Number: J555.962F
• Mol file: 146679-04-1.mol

Synonyms:N-[(3S)-2-oxopyrrolidin-3-yl]formamide;146679-04-1;SCHEMBL9197788;AKOS006358416;N-[(3S)-2-Oxopyrrolidin-3beta-yl]formamide;EN300-2971778

Chemical Property of N-[(3S)-2-oxopyrrolidin-3-yl]formamide

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 128.058577502
• Heavy Atom Count: 9
• Complexity: 135

Purity/Quality:

(S)-N-(2-OXO-3-PYRROLIDINYL)-FORMAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CNC(=O)C1NC=O
• Isomeric SMILES: C1CNC(=O)[C@H]1NC=O

Technology Process of N-[(3S)-2-oxopyrrolidin-3-yl]formamide

There total 2 articles about N-[(3S)-2-oxopyrrolidin-3-yl]formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

→ chloroform (67-66-3,8013-54-5) + (S)-3-(formylamino)-2-pyrrolidinone (146679-04-1)

Guidance literature:

Reference yield:

formic acid (64-18-6) + (3S)-3-aminopyrrolidin-2-one (4128-00-1) → (S)-3-(formylamino)-2-pyrrolidinone (146679-04-1)

Guidance literature:

With 1,1'-carbonyldiimidazole; Yield given. Multistep reaction; 1.) CH₂Cl₂, RT, 30 min, 2.) CH₂Cl₂, RT, 24 h;

DOI:10.1021/jm00063a001

upstream raw materials:

formic acid

(3S)-3-aminopyrrolidin-2-one

Refernces

• 1、 -. "3-Acylamino-2-pyrrolidinones as enhancers of the processes of learning and memory and pharmaceutical compositions containing same". . . Retrieved 2008/06/13.