1-Fluoro-2-[(4-fluorophenyl)ethynyl]benzene

Base Information

Chemical Name:1-Fluoro-2-[(4-fluorophenyl)ethynyl]benzene
CAS No.:148004-79-9
Molecular Formula:C14H8F2
Molecular Weight:214.214
Hs Code.:
DSSTox Substance ID:DTXSID50596781
Nikkaji Number:J2.225.905I
Wikidata:Q82492129
Mol file:148004-79-9.mol

Synonyms:148004-79-9;1-Fluoro-2-[(4-fluorophenyl)ethynyl]benzene;SCHEMBL9305673;DTXSID50596781

Suppliers and Price of 1-Fluoro-2-[(4-fluorophenyl)ethynyl]benzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Fluoro-2-[(4-fluorophenyl)ethynyl]benzene

Chemical Property:

XLogP3:4.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:214.05940658
Heavy Atom Count:16
Complexity:278

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C#CC2=CC=C(C=C2)F)F

Technology Process of 1-Fluoro-2-[(4-fluorophenyl)ethynyl]benzene

There total 6 articles about 1-Fluoro-2-[(4-fluorophenyl)ethynyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 766-98-3
1-ethynyl-4-fluorobenzene

: 348-52-7
1-Fluoro-2-iodobenzene

: 55606-94-5
1,4-bis(4'-fluorophenyl)-buta-1,3-diyne

: 148004-79-9
1-fluoro-2-((4-fluorophenyl)ethynyl)benzene

Guidance literature:: With triethylamine; palladium complex immobilised on silica gel; In various solvent(s); at 70 ℃; for 12h;
DOI:10.1016/j.tet.2005.06.082

Reference yield: 93.0%

: 1072-85-1
o-fluorobromobenzene

: 766-98-3
1-ethynyl-4-fluorobenzene

: 148004-79-9
1-fluoro-2-((4-fluorophenyl)ethynyl)benzene

Guidance literature:: o-fluorobromobenzene; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; for 0.25h; Inert atmosphere; Schlenk technique; Sealed tube;

1-ethynyl-4-fluorobenzene; at 80 ℃; for 24h; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.joc.0c01516

Reference yield: 87.0%

: 1246224-44-1
1-(bromoethynyl)-2-fluorobenzene

: p-fluorophenyltitanium triisopropoxide

: 148004-79-9
1-fluoro-2-((4-fluorophenyl)ethynyl)benzene

Guidance literature:: With bis(triphenylphosphine)nickel(II) chloride; N-ethyl-N,N-diisopropylamine; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; at 60 ℃; for 0.25h; Inert atmosphere;
DOI:10.1016/j.tet.2021.132370