(4R)-4-Ethyl-2-oxazolidinone

Base Information

• Chemical Name: (4R)-4-Ethyl-2-oxazolidinone
• CAS No.: 98974-04-0
• Molecular Formula: C5H9 N O2
• Molecular Weight: 115.132
• Mol file: 98974-04-0.mol

Synonyms:2-Oxazolidinone,4-ethyl-, (R)-; (+)-(4R)-4-Ethyl-2-oxazolidinone; (+)-4-Ethyloxazolidin-2-one;(R)-4-Ethyloxazolidin-2-one

Chemical Property of (4R)-4-Ethyl-2-oxazolidinone

Chemical Property:

• Vapor Pressure: 0.00124mmHg at 25°C
• Boiling Point: 298.9 °C at 760 mmHg
• Flash Point: 134.5 °C
• PSA: 38.33000
• Density: 1.047 g/cm³
• LogP: 0.83360

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4R)-4-Ethyl-2-oxazolidinone

There total 15 articles about (4R)-4-Ethyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-aminobutanol (96-20-8,13054-87-0) + carbon monoxide (201230-82-2) → 4-ethyl-2-oxazolidinone (13896-06-5,16112-60-0,98974-04-0,140388-18-7)

Guidance literature:

With selenium; oxygen; In acetonitrile; at 30 ℃; for 8h; under 760.051 Torr;

DOI:10.1016/j.tet.2007.09.037

Reference yield: 91.0%

2-aminobutanol (96-20-8,13054-87-0) + urea (57-13-6) → 4-ethyl-2-oxazolidinone (13896-06-5,16112-60-0,98974-04-0,140388-18-7)

Guidance literature:

With nitromethane; for 0.0916667h; Microwave irradiation;

Reference yield: 90.0%

2--1-butanol (13973-23-4) → 4-ethyl-2-oxazolidinone (13896-06-5,16112-60-0,98974-04-0,140388-18-7)

Guidance literature:

With potassium carbonate; at 125 - 130 ℃;

DOI:10.1002/adsc.200303006

upstream raw materials:

2-aminobutanol

Diethyl carbonate

phosgene

2,2'-dipyridyl carbonate

Downstream raw materials:

(2R,3R,4S)-4-(3,4-dimethoxyphenyl)-3-(3,4,5-trimethoxybenzyl)-2-((R)-4-ethyl-2-oxo-oxazolidin-3-yl)-3,4-dihydro-2H-pyran-6-carboxylic acid methyl ester

(2R,3R,4S)-4-(benzo[d][1,3]dioxol-5-yl)-3-(3,4,5-trimethoxybenzyl)-2-((R)-4-ethyl-2-oxo-oxazolidin-3-yl)-3,4-dihydro-2H-pyran-6-carboxylic acid methyl ester

(2R,3R,4S)-3-(3,4,5-trimethoxybenzyl)-4-(3,4,5-trimethoxyphenyl)-2-((R)-4-ethyl-2-oxo-oxazolidin-3-yl)-3,4-dihydro-2H-pyran-6-carboxylic acid methyl ester

(2R,3R,4S)-3-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(3,4-dimethoxyphenyl)-2-((R)-4-ethyl-2-oxo-oxazolidin-3-yl)-3,4-dihydro-2H-pyran-6-carboxylic acid methyl ester

Refernces

• 1、 -. "COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES". Page/Page column 119. . Retrieved 2019/07/19.
• 2、 Willer, Rodney L.,Campbell, Christopher G.,Storey, Robson F.. "Synthesis of cyclic N-nitrourethanes by the simultaneous oxidative desulfurization and nitration of cyclic thiourethanes". scheme or table. p. 421 - 423. Retrieved 2012/06/18.