Ethenamine, N,N-dimethyl-2-phenyl-, (E)-

Base Information

• Chemical Name: Ethenamine, N,N-dimethyl-2-phenyl-, (E)-
• CAS No.: 14846-39-0
• Molecular Formula: C10H13N
• Molecular Weight: 147.22
• Mol file: 14846-39-0.mol

Synonyms:

Chemical Property of Ethenamine, N,N-dimethyl-2-phenyl-, (E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethenamine, N,N-dimethyl-2-phenyl-, (E)-

There total 13 articles about Ethenamine, N,N-dimethyl-2-phenyl-, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N,N-dimethylammonium chloride (506-59-2) + phenylacetaldehyde (122-78-1) → E-2-(N,N-dimethylamino)-1-phenylethene (14846-39-0)

Guidance literature:

N,N-dimethylammonium chloride; phenylacetaldehyde; at 22 ℃; for 0.05h; Inert atmosphere;

In diethyl ether; for 0.0666667h; Inert atmosphere;

With triethylamine; In diethyl ether; at 22 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.joc.7b03187

Reference yield: 85.0%

N,N-dimethyl-2-phenylacetamide (18925-69-4) → E-2-(N,N-dimethylamino)-1-phenylethene (14846-39-0)

Guidance literature:

With trimethoxysilane; potassium tert-butylate; In tetrahydrofuran; at 65 ℃; for 14h; Sealed tube; Inert atmosphere;

DOI:10.1021/ol403302g

Reference yield: 75.0%

N,N-dimethylphenethylamine (1126-71-2) → N,N',N,N'-di(phenylethyl)dimethylethylenediamine (65838-16-6) + E-2-(N,N-dimethylamino)-1-phenylethene (14846-39-0)

Guidance literature:

With [2,2]bipyridinyl; iron(III) chloride; di-tert-butyl peroxide; In toluene; at 135 ℃; for 14h; Reagent/catalyst; Inert atmosphere;

DOI:10.1002/ejoc.202000293

upstream raw materials:

phenylacetaldehyde

dimethyl amine

1-dimethylamino-2-phenyl-ethyne

phenylacetic acid

Downstream raw materials:

N,N-dimethylphenethylamine

Refernces

• 1、 Javanmard, Sahar,Deutsch, Howard M.,Collard, David M.,Kuhar, Michael J.,Schweri, Margaret M.. "Synthesis and pharmacology of site-specific cocaine abuse treatment agents: 2-Substituted-6-amino-5-phenylbicyclo[2.2.2]octanes". . p. 4836 - 4843. Retrieved 1999.
• 2、 Slagbrand, Tove,Kervefors, Gabriella,Tinnis, Fredrik,Adolfsson, Hans. "An Efficient One–pot Procedure for the Direct Preparation of 4,5-Dihydroisoxazoles from Amides". supporting information. p. 1990 - 1995. Retrieved 2017/06/09.