N-diethoxyphosphanyl-N-ethylethanamine

Base Information

• Chemical Name: N-diethoxyphosphanyl-N-ethylethanamine
• CAS No.: 20262-87-7
• Molecular Formula: C8H20 N O2 P
• Molecular Weight: 193.226
• DSSTox Substance ID: DTXSID20364090
• Nikkaji Number: J1.130.879A
• Wikidata: Q82147857
• Mol file: 20262-87-7.mol

Synonyms:20262-87-7;Phosphoramidous acid, diethyl-, diethyl ester (6CI,7CI,8CI,9CI);Diethyl diethylphosphoramidite;N-diethoxyphosphanyl-N-ethylethanamine;diethyl diethylamidophosphite;Oprea1_264727;SCHEMBL1818590;DTXSID20364090;Diethyl N,N-diethylphosphoramidoite;(DIETHOXYPHOSPHANYL)DIETHYLAMINE;AKOS006230644;FT-0752400;N,N-Diethylamide phosphorous acid diethyl ester

Chemical Property of N-diethoxyphosphanyl-N-ethylethanamine

Chemical Property:

• Vapor Pressure: 3.18mmHg at 25°C
• Boiling Point: 154.4°C at 760 mmHg
• Flash Point: 47.2°C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 193.12316588
• Heavy Atom Count: 12
• Complexity: 93.1

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)P(OCC)OCC

Technology Process of N-diethoxyphosphanyl-N-ethylethanamine

There total 2 articles about N-diethoxyphosphanyl-N-ethylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

diethylamine (109-89-7) + diethyl trimethylsilyl phosphite (13716-45-5) → ethyl trimethylsilyl ether (1825-62-3) + diethyl diethylphosphoramidite (20262-87-7) + diethyl-phosphonamidic acid ethyl ester (16141-72-3)

Guidance literature:

at 100 ℃; for 1h;

DOI:10.1007/BF00959670

Reference yield: 30.0%

sodium diethyl phosphite (2303-76-6,118080-94-7) + diethylamine (109-89-7) → diethyl diethylphosphoramidite (20262-87-7) + sodium diethyl phosphate (2870-30-6) + phosphonic acid diethyl ester (762-04-9)

Guidance literature:

In acetonitrile; electrolysis;

Reference yield: 99.0%

diethyl diethylphosphoramidite (20262-87-7) + N-acetyl-L-tyrosine ethyl ester (840-97-1) → (+)-O-diethylphosphino-ethyl ester (213549-92-9)

Guidance literature:

In neat (no solvent); 100 deg C, 5 h; in vacou, 5 h;

DOI:10.1016/S0022-328X(99)00058-3

upstream raw materials:

sodium diethyl phosphite

diethylamine

diethyl trimethylsilyl phosphite

Downstream raw materials:

-essigsaeure-phenylester

3-(Diethoxy-phosphoryl)-2-diethylcarbamoyl-3-phenyl-propionic acid ethyl ester

Ethyl-4-ethoxyphenyl-(N-diethyl)-phosphoramidat

2-anilinoethyl diethyl phosphite