2-Amino-4-phenylthiophene-3-carboxamide

Base Information

• Chemical Name: 2-Amino-4-phenylthiophene-3-carboxamide
• CAS No.: 150302-19-5
• Molecular Formula: C11H10N2OS
• Molecular Weight: 0.00000
• European Community (EC) Number: 822-313-9
• Mol file: 150302-19-5.mol

Synonyms:2-amino-4-phenylthiophene-3-carboxamide;150302-19-5;2-amino-4-phenyl-3-thiophenecarboxamide;2-amino-4-phenyl-thiophene-3-carboxylic acid amide;3-Thiophenecarboxamide, 2-amino-4-phenyl-;SCHEMBL2368807;XYFVTAJLRZWIKJ-UHFFFAOYSA-N;BBL040907;STK399769;AKOS000308718;MCULE-4146437991;BS-31013;CS-0205937;EN300-228664;2-amino-4-phenylthiophene-3-carboxylic acid amide;2-amino-4-phenylthiophene-3-carboxamide, AldrichCPR;F2169-0938

Chemical Property of 2-Amino-4-phenylthiophene-3-carboxamide

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 218.05138412
• Heavy Atom Count: 15
• Complexity: 241

Purity/Quality:

99% ^*data from raw suppliers

2-amino-4-phenylthiophene-3-carboxamide ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CSC(=C2C(=O)N)N

Technology Process of 2-Amino-4-phenylthiophene-3-carboxamide

There total 2 articles about 2-Amino-4-phenylthiophene-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

acetophenone (98-86-2) + cyanoacetic acid amide (107-91-5) → 2-amino-4-phenylthiophene-3-carboxamide (150302-19-5)

Guidance literature:

With sulfur; In ethanol; for 20h; Temperature; Solvent; Reflux;

DOI:10.1080/17415993.2018.1436710

Reference yield:

phenylacetaldehyde (122-78-1) + cyanoacetic acid amide (107-91-5) → 2-amino-4-phenylthiophene-3-carboxamide (150302-19-5)

Guidance literature:

With sulfur; potassium fluoride on basic alumina; In ethanol; at 100 ℃; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.ejmech.2017.11.036

Reference yield: 74.0%

benzaldehyde (100-52-7) + 2-amino-4-phenylthiophene-3-carboxamide (150302-19-5) → 2,5-diphenylthieno[2,3-d]pyrimidin-4(3H)-one

Guidance literature:

In neat (no solvent); at 140 ℃;

DOI:10.1080/17415993.2018.1436710

upstream raw materials:

phenylacetaldehyde

cyanoacetic acid amide

acetophenone