2,4-Difluorophenyl ethyl carbonate

Base Information

• Chemical Name: 2,4-Difluorophenyl ethyl carbonate
• CAS No.: 152169-43-2
• Molecular Formula: C9H8F2O3
• Molecular Weight: 202.158
• DSSTox Substance ID: DTXSID20456580
• Wikidata: Q82279136
• Mol file: 152169-43-2.mol

Synonyms:2,4-difluorophenyl ethyl carbonate;152169-43-2;(2,4-difluorophenyl) Ethyl Carbonate;Ethyl 2,4-difluorophenoxycarboxylate;Carbonic acid, 2,4-difluorophenyl ethyl ester;SCHEMBL810613;2,4-difluorophenylethylcarbonate;DTXSID20456580;MBAMZRLDXCEBEA-UHFFFAOYSA-N;2,4-difluoro-O-ethoxycarbonylphenol;MFCD22375445;AKOS015991215;1R-1501

Chemical Property of 2,4-Difluorophenyl ethyl carbonate

Chemical Property:

• Boiling Point: 235.2±40.0 °C(Predicted)
• PSA: 35.53000
• Density: 1.276±0.06 g/cm3(Predicted)
• LogP: 2.50010
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 202.04415044
• Heavy Atom Count: 14
• Complexity: 199

Purity/Quality:

Ethyl2,4-Difluorophenoxycarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)OC1=C(C=C(C=C1)F)F

Technology Process of 2,4-Difluorophenyl ethyl carbonate

There total 1 articles about 2,4-Difluorophenyl ethyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,4-difluorophenol (367-27-1) + chloroformic acid ethyl ester (541-41-3) → 2,4-difluorophenyl ethyl carbonate (152169-43-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield: 84.0%

2,4-difluorophenyl ethyl carbonate (152169-43-2) → 2,4-difluoro-5-nitrophenol (113512-57-5)

Guidance literature:

2,4-difluorophenyl ethyl carbonate; With sulfuric acid; nitric acid; at 0 ℃; for 0.25h;

With sodium hydrogencarbonate; In methanol; at 20 ℃; for 16h;

Reference yield:

2,4-difluorophenyl ethyl carbonate (152169-43-2) → Carbonic acid 2,4-difluoro-5-nitro-phenyl ester ethyl ester

Guidance literature:

With sulfuric acid; nitric acid; at 10 - 20 ℃; for 1h;

DOI:10.1055/s-1997-1379

upstream raw materials:

2,4-difluorophenol

chloroformic acid ethyl ester

Downstream raw materials:

5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-4H-1-benzopyran-4-one

6,8-Difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-5-pivaloylamino-4H-1-benzopyran-4-one

2,4-difluoro-5-hydroxyaniline

2,4-difluoro-5-nitrophenol

Refernces

• 1、 -. "KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES". Page/Page column 34-35. . Retrieved 2008/06/13.
• 2、 -. "5-AMINOFLAVONE DERIVATIVES". . . Retrieved 2008/06/13.