158602-35-8

Basic information

• Product Name: 1-Boc-3-azetidineacetic acid ethyl ester
• Synonyms: 1-Boc-3-azetidineacetic acid ethyl ester;Ethyl 1-Boc-3-azetidineacetate;tert-Butyl 3-(2-ethoxy-2-oxoethyl)
• CAS NO: 158602-35-8
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 243.29944
• Mol File: 158602-35-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 303.0±15.0 °C(Predicted)
• Appearance: /
• Density: 1.089±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.89±0.40(Predicted)
• CAS DataBase Reference: 1-Boc-3-azetidineacetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-3-azetidineacetic acid ethyl ester(158602-35-8)
• EPA Substance Registry System: 1-Boc-3-azetidineacetic acid ethyl ester(158602-35-8)

Safety Data

• Hazardous Substances Data: 158602-35-8(Hazardous Substances Data)

Usage

General Description

"1-Boc-3-azetidineacetic acid ethyl ester" is a chemical compound often utilized in the field of organic chemistry, particularly in the production of pharmaceuticals. 1-Boc-3-azetidineacetic acid ethyl ester, which falls under the category of azetidines, plays a crucial role as a reagent or intermediate in the synthesis of more complex chemical entities. Its molecular structure comprises an ethyl ester group and a Boc-protected azetidine, making it an important building block in medicinal chemistry. The exact properties such as boiling point, melting point, or toxicity can vary depending on its specific derivation and should be ascertained in a controlled laboratory setting.

Upstream product

• 1002355-96-5 tert-butyl 3-(2-ethoxy-2-oxoethylidene)azetidine-1-carboxylate 
• 398489-26-4 tert-butyl 3-oxoazetidine-1-carboxylate 
• 183062-96-6 2-(1-(tert-butoxycarbonyl)azetidin-3-yl)acetic acid 

Downstream Products

• 712317-32-3 ethyl 2-(3-azetidinyl)acetate hydrochloride 
• 1332331-73-3 5-{[1-(cyclopropylcarbonyl)-3-azetidinyl]methyl}-4-[4-(1H-indazol-6-yl)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1332331-78-8 4-[4-(1-benzofuran-5-yl)phenyl]-5-{[1-(cyclopropylcarbonyl)-3-azetidinyl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 183062-96-6 2-(1-(tert-butoxycarbonyl)azetidin-3-yl)acetic acid 
• 152537-03-6 tert-butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate 

Relevant articles and documents

Intramolecular Ring-Opening Decomposition of Aryl Azetidines

The ring strain present in azetidines can lead to undesired stability issues. Herein, we described a series of N-substituted azetidines which undergo an acid-mediated intramolecular ring-opening decomposition via nucleophilic attack of a pendant amide group. Studies were conducted to understand the decomposition mechanism enabling the design of stable analogues.

DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES

The present invention provides, in part, compounds of Formula I, or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N- oxide, wherein: (R1)a, (R2)b, (R3)c, L, A, and E are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4- associated) disorders including, e.g., Alzheimer's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.

Fibrinogen receptor antagonists for inhibiting aggregation of blood platelets

Fibrinogen receptor antagonists of the formula: STR1 are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets.