8-Hydroxy-2-methoxy-1,4-naphthalenedione

Base Information

• Chemical Name: 8-Hydroxy-2-methoxy-1,4-naphthalenedione
• CAS No.: 15254-76-9
• Molecular Formula: C11H8O4
• Molecular Weight: 204.17900
• Hs Code.: 2914690090
• Mol file: 15254-76-9.mol

Synonyms:1,4-Naphthalenedione,8-hydroxy-2-methoxy;5-hydroxy-3-methoxy-1,4-naphthoquinone;5-Hydroxy-3-methoxy-1,4-naphthochinon;1,4-Naphthoquinone,8-hydroxy-2-methoxy;3-methoxy-5-hydroxy-1,4-naphthoquinone;3-Methoxyjuglon;3-Methoxyjuglone;

Chemical Property of 8-Hydroxy-2-methoxy-1,4-naphthalenedione

Chemical Property:

• Melting Point: 240 °C
• Boiling Point: 419.9±45.0 °C(Predicted)
• PKA: 6.40±0.20(Predicted)
• PSA: 63.60000
• Density: 1.41±0.1 g/cm3(Predicted)
• LogP: 1.30150

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-Hydroxy-2-methoxy-1,4-naphthalenedione

There total 24 articles about 8-Hydroxy-2-methoxy-1,4-naphthalenedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methanol (67-56-1) + 5-hydroxynaphtho-1,4-quinone (481-39-0) → 8-hydroxy-2-methoxynaphthalene-1,4-dione (15254-76-9) + 2-methoxy-5-hydroxy-1,4-naphthoquinone (15127-94-3)

Guidance literature:

With iron(III) sulfate; sulfuric acid; for 2h; Yields of byproduct given; Heating;

DOI:10.1002/ardp.19893220308

Reference yield: 84.0%

3,4-dihydro-8-hydroxy-5,7-dimethoxy-1(2H)-naphthalenone (82961-14-6) → 8-hydroxy-2-methoxynaphthalene-1,4-dione (15254-76-9)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; for 8h; Heating;

DOI:10.1002/hlca.19850680827

Reference yield: 82.0%

3,5-dihydroxy-2,3-dihydro-1,4-naphthoquinone (4923-58-4) + methyl iodide (74-88-4) → 8-hydroxy-2-methoxynaphthalene-1,4-dione (15254-76-9)

Guidance literature:

3,5-dihydroxy-2,3-dihydro-1,4-naphthoquinone; With sodium carbonate; In N,N-dimethyl-formamide;

methyl iodide; In N,N-dimethyl-formamide; for 10h;

DOI:10.1016/j.bmcl.2018.04.060

upstream raw materials:

methanol

5-hydroxynaphtho-1,4-quinone

3-chlorojuglone

3-Bromojuglone

Downstream raw materials:

3,5-dihydroxy-2,3-dihydro-1,4-naphthoquinone

2-Hydroxyjuglon