Trifluoroacetic acid cyclohexyl

Base Information

• Chemical Name: Trifluoroacetic acid cyclohexyl
• CAS No.: 1549-45-7
• Molecular Formula: C8H11F3O2
• Molecular Weight: 196.169
• Hs Code.: 2915900090
• Mol file: 1549-45-7.mol

Synonyms:trifluoroacetate of cyclohexanol;Acetic acid, trifluoro-, cyclohexyl ester;Trifluor-essigsaeure-cyclohexylester;Cyclohexyl-trifluoracetat;Trifluoroacetic acid,cyclohexyl ester;Trifluoressigsaeure-Cyclohexanolester;Acetic acid,trifluoro-,cyclohexyl ester;Cyclohexyl trifluoroacetate;

Chemical Property of Trifluoroacetic acid cyclohexyl

Chemical Property:

• Vapor Pressure: 1.48mmHg at 25°C
• Boiling Point: 170.3oC at 760 mmHg
• Flash Point: 39.2oC
• PSA: 26.30000
• Density: 1.2g/cm3
• LogP: 2.42460

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Trifluoroacetic acid cyclohexyl

There total 28 articles about Trifluoroacetic acid cyclohexyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(trifluoroacetyloxy)pyridine (96254-05-6) + cyclohexanol (108-93-0) → cyclohexyl trifluoroacetate (1549-45-7)

Guidance literature:

In diethyl ether; at 20 ℃; for 0.5h;

DOI:10.1246/bcsj.63.2252

Reference yield: 92.0%

cyclohexane (110-82-7,25012-93-5) + trifluoroacetic acid (76-05-1) → cyclohexyl trifluoroacetate (1549-45-7)

Guidance literature:

With tert-butylammonium hexafluorophosphate(V); trifluoroacetic anhydride; In dichloromethane; at 0 ℃;

Reference yield: 80.0%

1-(trifluoroacetyl)benzotriazole (183266-61-7) + cyclohexanol (108-93-0) → 1,2,3-Benzotriazole (95-14-7,27556-51-0) + cyclohexyl trifluoroacetate (1549-45-7)

Guidance literature:

In tetrahydrofuran; for 3h; Heating;

DOI:10.1021/jo961537r

upstream raw materials:

trifluoroacetic anhydride

cyclohexanol

Cyclohexyl iodide

silver trifluoroacetate

Downstream raw materials:

benzene

Adipic acid

trifluoroacetic acid

cyclohexyl 2,2-difluoro-2-(trimethylsilyl)acetate

Refernces

• 1、 Nordlander, J. Eric,Haky, Jerome E.,Landino, John P.. "Mechanism of Addition of Neat Trifluoroacetic Acid to Protoadamantene". . p. 7487 - 7493. Retrieved 1980.
• 2、 Moody, Christopher J.,O'Connell, Jenny L.. "Observations on the transition-metal catalysed oxidation of alkanes in trifluoroacetic acid: Urea-hydrogen peroxide/TFA as a convenient method for the oxidation of unactivated C-H bonds". . p. 1311 - 1312. Retrieved 2000.
• 3、 Haviv, Eynat,Herman, Adi,Khenkin, Alexander M.,Neumann, Ronny. "Electrocatalytic Oxyesterification of Hydrocarbons by Tetravalent Lead". . p. 10494 - 10501. Retrieved 2021.
• 4、 Coutard, Nathan,Goldberg, Jonathan M.,Valle, Henry U.,Cao, Yuan,Jia, Xiaofan,Jeffrey, Philip D.,Gunnoe, T. Brent,Groves, John T.. "Aerobic Partial Oxidation of Alkanes Using Photodriven Iron Catalysis". supporting information. p. 759 - 766. Retrieved 2022/01/11.