Tert-butyl 4-phenoxypiperidine-1-carboxylate

Base Information

• Chemical Name: Tert-butyl 4-phenoxypiperidine-1-carboxylate
• CAS No.: 155989-69-8
• Molecular Formula: C16H23NO3
• Molecular Weight: 277.364
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID30476754
• Wikidata: Q82308531
• Mol file: 155989-69-8.mol

Synonyms:TERT-BUTYL 4-PHENOXYPIPERIDINE-1-CARBOXYLATE;155989-69-8;1-Piperidinecarboxylic acid, 4-phenoxy-, 1,1-dimethylethyl ester;SCHEMBL5268593;DTXSID30476754;DEHLPJBINLOQIP-UHFFFAOYSA-N;AKOS013100992;FT-0737362;A855861;TERT-BUTYL4-PHENOXYPIPERIDINE-1-CARBOXYLATE;4-Phenoxy-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of Tert-butyl 4-phenoxypiperidine-1-carboxylate

Chemical Property:

• Melting Point: 65-68 °C
• Boiling Point: 374.5±35.0 °C(Predicted)
• PKA: -2.54±0.40(Predicted)
• PSA: 38.77000
• Density: 1.091±0.06 g/cm3(Predicted)
• LogP: 3.40280
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 277.16779360
• Heavy Atom Count: 20
• Complexity: 310

Purity/Quality:

97% ^*data from raw suppliers

tert-butyl4-phenoxypiperidine-1-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCC(CC1)OC2=CC=CC=C2

Technology Process of Tert-butyl 4-phenoxypiperidine-1-carboxylate

There total 6 articles about Tert-butyl 4-phenoxypiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) + phenol (108-95-2,27073-41-2) → tert-butyl 4-phenoxypiperidine-1-carboxylate (155989-69-8)

Guidance literature:

t-butyl 4-hydroxy piperidine-1-carboxylate; phenol; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

DOI:10.1055/s-2003-37520

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) + diethylazodicarboxylate (1972-28-7,218603-74-8) + phenol (108-95-2,27073-41-2) → tert-butyl 4-phenoxypiperidine-1-carboxylate (155989-69-8)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran;

Reference yield:

4-HYDROXYPIPERIDINE (5382-16-1) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-phenoxypiperidine-1-carboxylate (155989-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / tetrahydrofuran; water

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; water;

DOI:10.3390/molecules22101688

upstream raw materials:

t-butyl 4-hydroxy piperidine-1-carboxylate

phenol

4-HYDROXYPIPERIDINE

di-tert-butyl dicarbonate

Downstream raw materials:

4-phenoxypiperidine

4-(phenoxy)-piperidine hydrochloride

6-(4-phenoxypiperidin-1-yl)pyridazine-3-carbonitrile

N'-hydroxy-6-(4-phenoxypiperidin-1-yl)pyridazine-3-carboxamide