L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-O-[(1,1-dimethylethyl)dimethylsilyl]-3-[[( 1,1-dimethylethyl)dimethylsilyl]oxy]-

Base Information

Chemical Name:L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-O-[(1,1-dimethylethyl)dimethylsilyl]-3-[[( 1,1-dimethylethyl)dimethylsilyl]oxy]-
CAS No.:158955-67-0
Molecular Formula:C26H47NO6Si2
Molecular Weight:525.833
Hs Code.:
Mol file:158955-67-0.mol

Synonyms:

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Chemical Property of L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-O-[(1,1-dimethylethyl)dimethylsilyl]-3-[[( 1,1-dimethylethyl)dimethylsilyl]oxy]-

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Technology Process of L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-O-[(1,1-dimethylethyl)dimethylsilyl]-3-[[( 1,1-dimethylethyl)dimethylsilyl]oxy]-

There total 5 articles about L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-O-[(1,1-dimethylethyl)dimethylsilyl]-3-[[( 1,1-dimethylethyl)dimethylsilyl]oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 161392-58-1
3,4-bis(tert-butyldimethylsilyloxy)-L-phenylalanine

: 158955-67-0
(2S)-3-[3,4-bis[(tert-butyldimethylsilyl)oxy]phenyl]-2-[(tert-butoxycarbonyl)amino]propanoic acid

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; for 24h; Ambient temperature;

Reference yield: 39.0%

: 30033-24-0
(2S)-3-(3,4-dihydroxyphenyl)-2-[(tert-butoxy)carbonylamino]propanoic acid

: 18162-48-6
tert-butyldimethylsilyl chloride

: 158955-67-0
(2S)-3-[3,4-bis[(tert-butyldimethylsilyl)oxy]phenyl]-2-[(tert-butoxycarbonyl)amino]propanoic acid

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 0 - 20 ℃; for 16h;
DOI:10.1039/d1tb00742d

Reference yield:

: 59-92-7,90638-38-3
levodopa

: 158955-67-0
(2S)-3-[3,4-bis[(tert-butyldimethylsilyl)oxy]phenyl]-2-[(tert-butoxycarbonyl)amino]propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 18 h / 0 - 20 °C

2: sodium hydrogencarbonate / tetrahydrofuran; water / 24 h / 20 °C

With sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; water; acetonitrile;
DOI:10.3390/molecules22122076