(S)-2-{(S)-3-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-tert-butoxycarbonylamino-propionylamino}-4-methyl-pentanoic acid tert-butyl ester

Base Information

Chemical Name:(S)-2-{(S)-3-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-tert-butoxycarbonylamino-propionylamino}-4-methyl-pentanoic acid tert-butyl ester
CAS No.:161392-62-7
Molecular Formula:C₃₆H₆₆N₂O₇Si₂
Molecular Weight:695.1
Hs Code.:

(S)-2-{(S)-3-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-tert-butoxycarbonylamino-propionylamino}-4-methyl-pentanoic acid tert-butyl ester

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Chemical Property of (S)-2-{(S)-3-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-tert-butoxycarbonylamino-propionylamino}-4-methyl-pentanoic acid tert-butyl ester

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Technology Process of (S)-2-{(S)-3-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-tert-butoxycarbonylamino-propionylamino}-4-methyl-pentanoic acid tert-butyl ester

There total 5 articles about (S)-2-{(S)-3-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-tert-butoxycarbonylamino-propionylamino}-4-methyl-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 21691-53-2
L-leucine tert-butyl ester

: 158955-67-0
(2S)-3-[3,4-bis[(tert-butyldimethylsilyl)oxy]phenyl]-2-[(tert-butoxycarbonyl)amino]propanoic acid

: 161392-62-7
(S)-2-{(S)-3-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-tert-butoxycarbonylamino-propionylamino}-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In dichloromethane; for 24h; Ambient temperature;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 161392-62-7
(S)-2-{(S)-3-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-tert-butoxycarbonylamino-propionylamino}-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / NaHCO₃ / H₂O; tetrahydrofuran / 24 h / Ambient temperature

2: 63 percent / (1H-benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, N-methylmorpholine / CH₂Cl₂ / 24 h / Ambient temperature

With 4-methyl-morpholine; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 59-92-7,90638-38-3
levodopa

: 161392-62-7
(S)-2-{(S)-3-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-tert-butoxycarbonylamino-propionylamino}-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile / 18 h / Ambient temperature

2: 88 percent / NaHCO₃ / H₂O; tetrahydrofuran / 24 h / Ambient temperature

3: 63 percent / (1H-benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, N-methylmorpholine / CH₂Cl₂ / 24 h / Ambient temperature

With 4-methyl-morpholine; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; water; acetonitrile;