triethyl ester of 2-(4-(4-carboxyphenyl)butyl)-1,3-propanedioic acid

Base Information

• Chemical Name: triethyl ester of 2-(4-(4-carboxyphenyl)butyl)-1,3-propanedioic acid
• CAS No.: 80318-26-9
• Molecular Formula: C₂₀H₂₈O₆
• Molecular Weight: 364.439
• Mol file: 80318-26-9.mol

Synonyms:

Chemical Property of triethyl ester of 2-(4-(4-carboxyphenyl)butyl)-1,3-propanedioic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of triethyl ester of 2-(4-(4-carboxyphenyl)butyl)-1,3-propanedioic acid

There total 1 articles about triethyl ester of 2-(4-(4-carboxyphenyl)butyl)-1,3-propanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-(4-bromobutyl)benzoate (76865-46-8) + diethyl malonate (105-53-3) → triethyl ester of 2-(4-(4-carboxyphenyl)butyl)-1,3-propanedioic acid (80318-26-9)

Guidance literature:

With sodium ethanolate; Multistep reaction; 1. ethanol, reflux 10 min; 2. reflux 6 h;

DOI:10.1135/cccc19812217

Reference yield:

guanidine hydrochloride (50-01-1) + triethyl ester of 2-(4-(4-carboxyphenyl)butyl)-1,3-propanedioic acid (80318-26-9) → 4-[4-(2-Amino-4-hydroxy-6-oxo-1,6-dihydro-pyrimidin-5-yl)-butyl]-benzoic acid (80305-90-4)

Guidance literature:

With sodium hydroxide; sodium methylate; Yield given. Multistep reaction; 1. methanol, room temperature 4 h; 2. water, room temperature 2 h;

DOI:10.1135/cccc19812217

upstream raw materials:

ethyl 4-(4-bromobutyl)benzoate

diethyl malonate

Downstream raw materials:

4-[4-(2-Amino-4-hydroxy-6-oxo-1,6-dihydro-pyrimidin-5-yl)-butyl]-benzoic acid