4-(Phenylsulfinyl)morpholine

Base Information

• Chemical Name: 4-(Phenylsulfinyl)morpholine
• CAS No.: 16066-32-3
• Molecular Formula: C10H13NO2S
• Molecular Weight: 211.285
• DSSTox Substance ID: DTXSID501309618
• Nikkaji Number: J774.647D
• Mol file: 16066-32-3.mol

Synonyms:4-(phenylsulfinyl)morpholine;benzenesulfinyl morpholine;16066-32-3;4-(benzenesulfinyl)-morpholine;SCHEMBL6677443;DTXSID501309618

Chemical Property of 4-(Phenylsulfinyl)morpholine

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 211.06669983
• Heavy Atom Count: 14
• Complexity: 198

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1COCCN1S(=O)C2=CC=CC=C2

Technology Process of 4-(Phenylsulfinyl)morpholine

There total 11 articles about 4-(Phenylsulfinyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-(benzoyloxy)morpholine (5765-65-1) + tert-butyl 3-[(phenyl)sulfinyl]propanoate → 4-(benzenesulfinyl)morpholine (16066-32-3)

Guidance literature:

With [2,2]bipyridinyl; copper(l) iodide; lithium tert-butoxide; In toluene; at 10 ℃; for 5h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;

DOI:10.1002/adsc.201701510

Reference yield: 93.0%

4-Phenylsulfanyl-morpholine (4837-31-4) → 4-(benzenesulfinyl)morpholine (16066-32-3)

Guidance literature:

With sodium bromite; In 1,4-dioxane; water; for 0.25h; Ambient temperature;

DOI:10.1055/s-1983-30526

Reference yield: 83.0%

4-(benzoyloxy)morpholine (5765-65-1) + benzenesulfinamide (16066-31-2,33903-53-6) → 4-(benzenesulfinyl)morpholine (16066-32-3)

Guidance literature:

With triphenylphosphine; copper(ll) bromide; In 1,2-dichloro-ethane; at 60 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201810548

upstream raw materials:

4-Phenylsulfanyl-morpholine

morpholine

benzenesulfenyl chloride

methyl benzenesulfinate

Downstream raw materials:

4-benzenesulfonylmorpholine

4-(S-phenylsulfonimidoyl)morpholine

Refernces

• 1、 Li, Gang-Jian,Pan, You-Lu,Liu, Yan-Ling,Xu, Hai-Feng,Chen, Jian-Zhong. "Ni/NHC-catalyzed cross-coupling of methyl sulfinates and amines for direct access to sulfinamides". supporting information. . Retrieved 2019/10/28.
• 2、 Izzo, Flavia,Sch?fer, Martina,Stockman, Robert,Lücking, Ulrich. "A New, Practical One-Pot Synthesis of Unprotected Sulfonimidamides by Transfer of Electrophilic NH to Sulfinamides". . p. 15189 - 15193. Retrieved 2017/10/12.