Methanamine, N-[(4-methoxyphenyl)methylene]-, N-oxide

Base Information

• Chemical Name: Methanamine, N-[(4-methoxyphenyl)methylene]-, N-oxide
• CAS No.: 16089-66-0
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.192
• DSSTox Substance ID: DTXSID00363041
• Nikkaji Number: J497.810B
• Mol file: 16089-66-0.mol

Synonyms:Bionet2_000146;SCHEMBL9632582;Methanamine, N-[(4-methoxyphenyl)methylene]-, N-oxide;DTXSID00363041;16089-66-0;Methyloxylato(4-methoxybenzylidene)iminium

Chemical Property of Methanamine, N-[(4-methoxyphenyl)methylene]-, N-oxide

Chemical Property:

• PSA: 37.98000
• LogP: 1.77740
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 165.078978594
• Heavy Atom Count: 12
• Complexity: 160

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[N+](=CC1=CC=C(C=C1)OC)[O-]

Technology Process of Methanamine, N-[(4-methoxyphenyl)methylene]-, N-oxide

There total 7 articles about Methanamine, N-[(4-methoxyphenyl)methylene]-, N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-methylhydroxyamine hydrochloride (4229-44-1) + 4-methoxy-benzaldehyde (123-11-5) → C-(4-methoxyphenyl)-N-methyl nitrone (16089-66-0,102972-06-5,203731-09-3)

Guidance literature:

N-methylhydroxyamine hydrochloride; With sodium carbonate; In methanol; at 20 ℃; for 0.0833333h;

4-methoxy-benzaldehyde; In methanol; at 20 ℃; for 12h;

DOI:10.1016/j.molstruc.2016.08.058

Reference yield: 76.0%

α,α-adamantylidene-N-methyl nitrone (57777-70-5) + 4-methoxy-benzaldehyde (123-11-5) → 2-Adamantanone (700-58-3) + C-(4-methoxyphenyl)-N-methyl nitrone (16089-66-0,102972-06-5,203731-09-3)

Guidance literature:

In toluene; for 26h; Heating;

DOI:10.1002/hlca.19900730119

Reference yield: 72.0%

N-Methylhydroxylamine (593-77-1) + 4-methoxy-benzaldehyde (123-11-5) → C-(4-methoxyphenyl)-N-methyl nitrone (16089-66-0,102972-06-5,203731-09-3)

Guidance literature:

With sodium acetate; at 159 ℃; for 0.0583333h; microwave irradiation;

DOI:10.1016/j.tet.2008.08.101

upstream raw materials:

N-p-methoxybenzyl-N-methylhydroxylamine

α,α-adamantylidene-N-methyl nitrone

4-methoxy-benzaldehyde

N-methylhydroxyamine hydrochloride

Downstream raw materials:

(3S*,3aS*,7S*,7aR*)-7-benzoyloxy-3-p-methoxyphenyl-2-methyl-4-oxo-tetrahydropyrano-<4,5-d>-isoxazolidine

2-methyl-3-p-methoxyphenyl-5-ethoxyisoxazolidine

2-methyl-3-p-methoxyphenyl-5-ethoxyisoxazolidine

4-ethoxycarbonyl-3-(4'-methoxyphenyl)-2-methyl-5-phenyl-4-isoxazoline