7-chloro-2-(chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one

Base Information

Chemical Name:7-chloro-2-(chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one
CAS No.:162469-87-6
Molecular Formula:C9H6Cl2N2O
Molecular Weight:229.06300
Hs Code.:2933990090
DSSTox Substance ID:DTXSID60403013
Wikidata:Q82206545
Mol file:162469-87-6.mol

Synonyms:7-chloro-2-(chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one;162469-87-6;7-chloro-2-(chloromethyl)pyrido[1,2-a]pyrimidin-4-one;4H-Pyrido[1,2-a]pyrimidin-4-one, 7-chloro-2-(chloromethyl)-;SCHEMBL3152080;DTXSID60403013;MFCD02650641;AKOS000265081;VS-09391;BB 0262713;EU-0093622;EN300-14726;G11885;SR-01000068484;J-009940;SR-01000068484-1;Z89265797;F0912-2376;7-chloro-2-(chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one(SALTDATA: FREE)

Suppliers and Price of 7-chloro-2-(chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
7-Chloro-2-(chloromethyl)-4h-pyrido[1,2-a]pyrimidin-4-one
100mg
$ 60.00

TRC
7-Chloro-2-(chloromethyl)-4h-pyrido[1,2-a]pyrimidin-4-one
50mg
$ 45.00

SynChem
7-CHLORO-2-(CHLOROMETHYL)-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE 95%
1 g
$ 650.00

Crysdot
7-Chloro-2-(chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one 95+%
5g
$ 564.00

Chemcia Scientific
7-Chloro-2-(chloromethyl)-4h-pyrido[1,2-a]pyrimidin-4-one ＞98%
0.5 G
$ 100.00

Biosynth Carbosynth
7-Chloro-2-(chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one
250 mg
$ 160.00

Biosynth Carbosynth
7-Chloro-2-(chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one
500 mg
$ 250.00

Biosynth Carbosynth
7-Chloro-2-(chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one
100 mg
$ 100.00

Biosynth Carbosynth
7-Chloro-2-(chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one
50 mg
$ 65.00

Biosynth Carbosynth
7-Chloro-2-(chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one
1 g
$ 450.00

Total 11 raw suppliers

Chemical Property of 7-chloro-2-(chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one

Chemical Property:

Melting Point:156 °C(Solv: isopropanol (67-63-0))
Boiling Point:309.0±52.0 °C(Predicted)
PKA:0.77±0.70(Predicted)
PSA：34.37000
Density:1.50±0.1 g/cm3(Predicted)
LogP:2.08670
XLogP3:0.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:227.9857182
Heavy Atom Count:14
Complexity:407

Purity/Quality:

98%Min ^*data from raw suppliers

7-Chloro-2-(chloromethyl)-4h-pyrido[1,2-a]pyrimidin-4-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=NC(=CC(=O)N2C=C1Cl)CCl

Technology Process of 7-chloro-2-(chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one

There total 2 articles about 7-chloro-2-(chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1072-98-6
5-chloro-2-pyridylamine

: 638-07-3
ethyl (2-chloroaceto)acetate

: 162469-87-6
2-chloromethyl-6-chloro-4H-pyrido<1,2-a>pyrimidin-4-one

Guidance literature:: With polyphosphoric acid; at 110 ℃; for 3h;
DOI:10.1055/s-0030-1260197

Reference yield: 43.0%

: 817206-07-8
7-chloro-2-(chloromethyl)-3-iodo-4H-pyrido[1,2-a]pyrimidin-4-one

: 162469-87-6
2-chloromethyl-6-chloro-4H-pyrido<1,2-a>pyrimidin-4-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4-methoxyphenylboronic acid; potassium carbonate; In 1,2-dimethoxyethane; ethanol; at 80 ℃; for 2h; Microwave irradiation;
DOI:10.1055/s-0030-1260197

Reference yield:

: 162469-87-6
2-chloromethyl-6-chloro-4H-pyrido<1,2-a>pyrimidin-4-one

: 1350908-12-1
(E)-[7-chloro-3-(4-methylstyryl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl]methyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodo-succinimide / acetonitrile / 16 h / Reflux

2: N,N-dimethyl-formamide / 5 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; ethanol / 2 h / 100 °C / Microwave irradiation

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; acetonitrile; 3: Suzuki coupling;
DOI:10.1055/s-0030-1260197