Pyrrolidine, 1-nitroso-2-[(phenylmethoxy)methyl]-, (2S)-

Base Information

Chemical Name:Pyrrolidine, 1-nitroso-2-[(phenylmethoxy)methyl]-, (2S)-
CAS No.:162755-95-5
Molecular Formula:C12H16N2O2
Molecular Weight:220.271
Hs Code.:
DSSTox Substance ID:DTXSID00439619
Wikidata:Q82255620
Mol file:162755-95-5.mol

Synonyms:162755-95-5;Pyrrolidine, 1-nitroso-2-[(phenylmethoxy)methyl]-, (2S)-;DTXSID00439619

Suppliers and Price of Pyrrolidine, 1-nitroso-2-[(phenylmethoxy)methyl]-, (2S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrrolidine, 1-nitroso-2-[(phenylmethoxy)methyl]-, (2S)-

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:220.121177757
Heavy Atom Count:16
Complexity:217

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(N(C1)N=O)COCC2=CC=CC=C2
Isomeric SMILES:C1C[C@H](N(C1)N=O)COCC2=CC=CC=C2

Technology Process of Pyrrolidine, 1-nitroso-2-[(phenylmethoxy)methyl]-, (2S)-

There total 1 articles about Pyrrolidine, 1-nitroso-2-[(phenylmethoxy)methyl]-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 58246-54-1
1-Nitroso-2(S)-pyrrolidinemethanol

: 100-39-0
benzyl bromide

: 162755-95-5
(S)-2-<(Benzyloxy)methyl>-N-nitrosopyrrolidine

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1016/0040-4039(94)02376-M

Reference yield:

: 162755-95-5
(S)-2-<(Benzyloxy)methyl>-N-nitrosopyrrolidine

: 162755-96-6
(S)-1-Amino-2-<(benzyloxy)methyl>pyrrolidine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;
DOI:10.1016/0040-4039(94)02376-M

Reference yield:

: 162755-95-5
(S)-2-<(Benzyloxy)methyl>-N-nitrosopyrrolidine

: (6RS)-N-<(2S)-2-<(Benzyloxy)methyl>pyrrolidino>-6-hydroxy-2-piperidinone

Guidance literature:: Multi-step reaction with 3 steps

1: LiAlH₄ / tetrahydrofuran / 1.) room temp., 15 min, 2.) reflux, 2 h

2: 2.) Ac₂O, NaOAc / 1.) CH₂Cl₂, room temp., 1 h, 2.) reflux, 1 h

3: 80 percent / LiEt₃BH / tetrahydrofuran / 2 h / -78 °C

With lithium aluminium tetrahydride; sodium acetate; acetic anhydride; lithium triethylborohydride; In tetrahydrofuran;
DOI:10.1021/jo00124a025