4-(2-Hydroxy-ethoxy)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-(2-Hydroxy-ethoxy)-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 163210-40-0
• Molecular Formula: C12H23NO4
• Molecular Weight: 245.319
• Mol file: 163210-40-0.mol

Synonyms:2-(1-(tert-butoxycarbonyl)-4-piperidyloxy)-ethanol;4-(2-hydroxyethoxy)-1-piperidinecarboxylic acid,1,1-dimethylethyl ester;2-[1-(tert-butoxycarbonyl)piperidin-4-yloxy]ethanol;2-((1-tertbutoxycarbonyl)piperidin-4-yloxy)ethanol;4-(2-hydroxy-ethoxy)-piperidine-1-carboxylic acid tert-butyl ester;4-(2-hydroxyethoxy)piperidine-1-carboxylic acid tert-butyl ester;

Chemical Property of 4-(2-Hydroxy-ethoxy)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

• PSA: 59.00000
• LogP: 1.33270

Purity/Quality:

99% ^*data from raw suppliers

tert-butyl4-(2-hydroxyethoxy)piperidine-1-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-Hydroxy-ethoxy)-piperidine-1-carboxylic acid tert-butyl ester

There total 12 articles about 4-(2-Hydroxy-ethoxy)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-piperidone ethylene glycol ketal (40256-14-2) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-(2-hydroxyethoxy)piperidine-1-carboxylate (163210-40-0)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 6h;

Reference yield: 94.0%

4-(ethoxycarbonylmethoxy)piperidine-1-carboxylic acid tert-butylester (189889-45-0) → tert-butyl 4-(2-hydroxyethoxy)piperidine-1-carboxylate (163210-40-0)

Guidance literature:

With lithium borohydride; lithium triethylborohydride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 12h;

DOI:10.1021/acs.jmedchem.6b01586

Reference yield: 90.0%

tert-butyl4-tert-butoxycarbonylmethoxypiperidine-1-carboxylate (507224-67-1) → tert-butyl 4-(2-hydroxyethoxy)piperidine-1-carboxylate (163210-40-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2.5h; Cooling with ice;

upstream raw materials:

4,4-(ethylenedioxy)-1-tertbutoxycarbonylpiperidine

tert-butyl 4-(allyloxy)piperidine-1-carboxylate

dichloromethane

4-(carboxymethoxy)piperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

Methyl 4-[2-(N-Boc-Piperidin-4-yloxy)ethyloxy]benzoate

4-piperidone ethylene glycol ketal

tert-butyl 4-{2-[({[(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}amino)oxy]ethoxy}piperidine-1-carboxylate