1-Boc-4-ethoxycarbonylmethoxypiperidine

Base Information

• Chemical Name: 1-Boc-4-ethoxycarbonylmethoxypiperidine
• CAS No.: 189889-45-0
• Molecular Formula: C₁₄H₂₅NO₅
• Molecular Weight: 287.356
• DSSTox Substance ID: DTXSID30441189
• Wikidata: Q82257836
• Mol file: 189889-45-0.mol

Synonyms:1-Boc-4-ethoxycarbonylmethoxypiperidine;189889-45-0;tert-butyl 4-(2-ethoxy-2-oxoethoxy)piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-(2-ethoxy-2-oxoethoxy)-, 1,1-dimethylethyl ester;F2158-1141;SCHEMBL6319049;DTXSID30441189;BTANMNWDTQXBSP-UHFFFAOYSA-N;MFCD06858765;AKOS015897857;AT13063;CS-0370179;FT-0710224;EN300-237980;1-t-Butoxycarbonyl-4-ethoxycarbonylmethoxypiperidine;tert-butyl 4-(2-ethoxy-2-oxoethoxy)-1-piperidine carboxylate;tert-butyl 4-(2-ethoxy-2-oxoethoxy)-1-piperidine-carboxylate;4-(ethoxycarbonylmethoxy)piperidine-1-carboxylic acid tert-butylester;4-Ethoxycarbonylmethoxy-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 1-Boc-4-ethoxycarbonylmethoxypiperidine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.48
• Boiling Point: 381.251 °C at 760 mmHg
• Flash Point: 184.374 °C
• PSA: 65.07000
• Density: 1.101 g/cm³
• LogP: 1.90350
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• Exact Mass: 287.17327290
• Heavy Atom Count: 20
• Complexity: 329

Purity/Quality:

99% ^*data from raw suppliers

1-BOC-4-ETHOXYCARBONYLMETHOXYPIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)COC1CCN(CC1)C(=O)OC(C)(C)C

Technology Process of 1-Boc-4-ethoxycarbonylmethoxypiperidine

There total 3 articles about 1-Boc-4-ethoxycarbonylmethoxypiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

diazoacetic acid ethyl ester (623-73-4) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 4-(ethoxycarbonylmethoxy)piperidine-1-carboxylic acid tert-butylester (189889-45-0)

Guidance literature:

With rhodium(II) acetate; In dichloromethane; at 0 - 25 ℃; for 42h;

Reference yield: 76.0%

diazoacetic acid ethyl ester (623-73-4) + dirhodium tetraacetate + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 4-(ethoxycarbonylmethoxy)piperidine-1-carboxylic acid tert-butylester (189889-45-0)

Guidance literature:

In dichloromethane;

Reference yield: 70.0%

ethyl bromoacetate (105-36-2) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 4-(ethoxycarbonylmethoxy)piperidine-1-carboxylic acid tert-butylester (189889-45-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; Inert atmosphere;

upstream raw materials:

diazoacetic acid ethyl ester

t-butyl 4-hydroxy piperidine-1-carboxylate

ethyl bromoacetate

Downstream raw materials:

4-(carboxymethoxy)piperidine-1-carboxylic acid tert-butyl ester

4-[(methyl-{1-[methyl-(1-methylcarbamoyl-2-phenyl-ethyl)-carbamoyl]-2-naphthalen-2-yl-ethyl}-carbamoyl)-methoxy]-piperidine-1-carboxylic acid tert-butyl ester

4-nitrophenyl 4-(2-ethoxy-2-oxoethoxy)-1-piperidinecarboxylate

tert-butyl 4-((5-amino-1-phenyl-1H-pyrazol-3-yl)methoxy)piperidine-1-carboxylate