N-Cyclohexyl-N-(phenylmethyl)benzenemethanamine

Base Information

• Chemical Name: N-Cyclohexyl-N-(phenylmethyl)benzenemethanamine
• CAS No.: 16350-97-3
• Molecular Formula: C20H25N
• Molecular Weight: 279.425
• DSSTox Substance ID: DTXSID501241802
• Nikkaji Number: J2.803.139D
• Mol file: 16350-97-3.mol

Synonyms:SCHEMBL515999;DTXSID501241802;16350-97-3;N-Cyclohexyl-N-(phenylmethyl)benzenemethanamine

Chemical Property of N-Cyclohexyl-N-(phenylmethyl)benzenemethanamine

Chemical Property:

• XLogP3: 5.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 279.198699802
• Heavy Atom Count: 21
• Complexity: 250

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCC(CC1)N(CC2=CC=CC=C2)CC3=CC=CC=C3

Technology Process of N-Cyclohexyl-N-(phenylmethyl)benzenemethanamine

There total 18 articles about N-Cyclohexyl-N-(phenylmethyl)benzenemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

benzyl bromide (100-39-0) + cyclohexylamine (108-91-8,157973-60-9) → N-cyclohexyl-N,N-dibenzylamine (16350-97-3)

Guidance literature:

cyclohexylamine; With caesium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 0.5h;

benzyl bromide; In N,N-dimethyl-formamide; at 25 ℃; for 24h; chemoselective reaction; Microwave irradiation;

DOI:10.1002/ejoc.201600549

Reference yield: 88.0%

N,N-dibenzyl-O-benzoylhydroxylamine (52742-32-2) + cyclohexylmagnesium bromide (931-50-0) → N-cyclohexyl-N,N-dibenzylamine (16350-97-3)

Guidance literature:

With copper dichloride; In tetrahydrofuran; at 20 ℃; for 0.25h;

DOI:10.1021/ol0702829

Reference yield: 70.0%

cyclohexylamine (108-91-8,157973-60-9) + benzyl alcohol (100-51-6,185532-71-2) → N-cyclohexyl-N,N-dibenzylamine (16350-97-3)

Guidance literature:

at 145 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tet.2016.11.029

upstream raw materials:

phenyldiazomethane

cyclohexylamine

cyclohexyl-3 perhydrodioxazepine-1,5,3

benzaldehyde

Downstream raw materials:

benzyl-cyclohexyl-nitroso-amine

N-benzoylcyclohexylamine