4,5-diphenyl-2-(2-thienyl)-1H-imidazole

Base Information

• Chemical Name: 4,5-diphenyl-2-(2-thienyl)-1H-imidazole
• CAS No.: 16408-55-2
• Molecular Formula: C19H14N2S
• Molecular Weight: 302.4
• DSSTox Substance ID: DTXSID50354267
• Nikkaji Number: J1.350.406G
• Wikidata: Q82132311
• Pharos Ligand ID: 4CHCBK2CMT5X
• ChEMBL ID: CHEMBL1530194
• Mol file: 16408-55-2.mol

Synonyms:4,5-diphenyl-2-(2-thienyl)-1H-imidazole;16408-55-2;Maybridge4_002049;Oprea1_292467;MLS000571251;CHEMBL1530194;SCHEMBL14059826;DTXSID50354267;HMS1526N03;HMS2457K11;STK877591;AKOS005609193;SMR000193618;4,5-diphenyl-2-(thiophen-2-yl)-1H-imidazole;4,5-diphenyl-2-(thiophen-2-yl)-1 h -imidazole;BRD-K82825850-001-01-5

Chemical Property of 4,5-diphenyl-2-(2-thienyl)-1H-imidazole

Chemical Property:

• PSA: 56.92000
• LogP: 5.47220
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 302.08776963
• Heavy Atom Count: 22
• Complexity: 349

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(N=C(N2)C3=CC=CS3)C4=CC=CC=C4

Technology Process of 4,5-diphenyl-2-(2-thienyl)-1H-imidazole

There total 6 articles about 4,5-diphenyl-2-(2-thienyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

thiophene-2-carbaldehyde (98-03-3) + benzil (134-81-6) → 4,5-diphenyl-2-(2-thienyl)-1H-imidazole (16408-55-2)

Guidance literature:

With C₉H₁₉N₂O₂⁽¹⁺⁾*C₂H₃O₂^(1-); ammonium acetate; water; at 60 ℃; for 0.0833333h; Sonication; Green chemistry;

DOI:10.1039/c8ra02755b

Reference yield: 97.0%

thiophene-2-carbaldehyde (98-03-3) + 2-hydroxy-2-phenylacetophenone (119-53-9,579-44-2) → 4,5-diphenyl-2-(2-thienyl)-1H-imidazole (16408-55-2)

Guidance literature:

With ammonium acetate; In ethanol; for 0.75h; Reflux;

DOI:10.1039/c6ra14550g

Reference yield: 86.0%

thiophene-2-carbaldehyde (98-03-3) + ammonium acetate (631-61-8,92206-38-7) + benzil (134-81-6) → 4,5-diphenyl-2-(2-thienyl)-1H-imidazole (16408-55-2)

Guidance literature:

With C₁₄H₁₈MnNO₈; In ethanol; Reflux;

DOI:10.1007/s10562-021-03717-2

upstream raw materials:

thiophene-2-carbaldehyde

benzil

2-hydroxy-2-phenylacetophenone

phenyl benzyl ketone

Downstream raw materials:

5-(1-methyl-4,5-diphenyl-1H-imidazol-2-yl)-thiophene-2-carbaldehyde

1-Methyl-4,5-diphenyl-2-thiophen-2-yl-1H-imidazole

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