4-(aminomethyl)cyclohexanol

Base Information

• Chemical Name: 4-(aminomethyl)cyclohexanol
• CAS No.: 164646-07-5
• Molecular Formula: C7H15NO
• Molecular Weight: 129.202
• Mol file: 164646-07-5.mol

Synonyms:Cyclohexanol,4-(aminomethyl);4-(AMINOMETHYL)CYCLOHEXANOL;(trans)-(4-hydroxy-cyclohexyl)-methyl-amine;4-(Aminomethyl)-cyclohexanol HCl;4-hydroxycyclohexylmethylamine;

Chemical Property of 4-(aminomethyl)cyclohexanol

Chemical Property:

• Boiling Point: 226.4±13.0 °C(Predicted)
• PKA: 15.21±0.40(Predicted)
• PSA: 46.25000
• Density: 1.007±0.06 g/cm3(Predicted)
• LogP: 1.19650

Purity/Quality:

95-99% ^*data from raw suppliers

4-(Aminomethyl)cyclohexanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(aminomethyl)cyclohexanol

There total 3 articles about 4-(aminomethyl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(hydroxymethyl)cyclohexan-1-ol (33893-85-5) → (trans)-(4-hydroxy-cyclohexyl)-methyl-amine (164646-07-5)

Guidance literature:

4-(hydroxymethyl)cyclohexan-1-ol; With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; at 0 ℃; for 2h;

With sodium azide; In N,N-dimethyl-formamide; at 60 ℃;

With hydrogen; palladium 10% on activated carbon; In methanol;

Reference yield:

N-benzyl-N-(4-hydroxycyclohexylmethyl)-amine → (trans)-(4-hydroxy-cyclohexyl)-methyl-amine (164646-07-5)

Guidance literature:

With ammonium formate; palladium; In methanol; dichloromethane;

Reference yield:

N-methyl-p-aminophenol (150-75-4) + rhodium (378784-00-0,7440-16-6) → (trans)-(4-hydroxy-cyclohexyl)-methyl-amine (164646-07-5)

Guidance literature:

With sodium hydroxide; In water;

upstream raw materials:

N-methyl-p-aminophenol

rhodium

4-(hydroxymethyl)cyclohexan-1-ol

Downstream raw materials:

pyrrolidine-1-carboxylic acid (4-hydroxy-cyclohexylmethyl)-amide

pyridin-4-ylmethyl-carbamic acid 4-{[(pyrrolidine-1-carbonyl)-amino]-methyl}-cyclohexyl ester

Refernces

• 1、 -. "NOVEL METHYLCYCLOHEXANE DERIVATIVES AND USES THEREOF". Paragraph 282-285. . Retrieved 2012/04/17.
• 2、 -. "AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND THEIR USE IN THE TREATMENT OF OBESITY". . . Retrieved 2008/06/13.