pyridin-4-ylmethyl-carbamic acid 4-{[(pyrrolidine-1-carbonyl)-amino]-methyl}-cyclohexyl ester

Base Information

• Chemical Name: pyridin-4-ylmethyl-carbamic acid 4-{[(pyrrolidine-1-carbonyl)-amino]-methyl}-cyclohexyl ester
• CAS No.: 1369590-83-9
• Molecular Formula: C₁₉H₂₈N₄O₃
• Molecular Weight: 360.456
• Mol file: 1369590-83-9.mol

Synonyms:pyridin-4-ylmethyl-carbamic acid 4-{[(pyrrolidine-1-carbonyl)-amino]-methyl}-cyclohexyl ester

Chemical Property of pyridin-4-ylmethyl-carbamic acid 4-{[(pyrrolidine-1-carbonyl)-amino]-methyl}-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of pyridin-4-ylmethyl-carbamic acid 4-{[(pyrrolidine-1-carbonyl)-amino]-methyl}-cyclohexyl ester

There total 3 articles about pyridin-4-ylmethyl-carbamic acid 4-{[(pyrrolidine-1-carbonyl)-amino]-methyl}-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(aminomethyl)pyridine (3731-53-1) + pyrrolidine-1-carboxylic acid (4-hydroxy-cyclohexylmethyl)-amide (1369590-92-0) + 1,1'-carbonyldiimidazole (530-62-1) → pyridin-4-ylmethyl-carbamic acid 4-{[(pyrrolidine-1-carbonyl)-amino]-methyl}-cyclohexyl ester (1369590-83-9)

Guidance literature:

pyrrolidine-1-carboxylic acid (4-hydroxy-cyclohexylmethyl)-amide; 1,1'-carbonyldiimidazole; In acetonitrile; at 80 ℃; for 1h;

With methyl iodide; In acetonitrile; at 80 ℃; for 1h;

4-(aminomethyl)pyridine; In acetonitrile; at 80 ℃; for 4h;

Reference yield:

4-(hydroxymethyl)cyclohexan-1-ol (33893-85-5) → pyridin-4-ylmethyl-carbamic acid 4-{[(pyrrolidine-1-carbonyl)-amino]-methyl}-cyclohexyl ester (1369590-83-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 2 h / 0 °C

1.2: 60 °C

2.1: triethylamine / dichloromethane / 20 °C

3.1: acetonitrile / 1 h / 80 °C

3.2: 1 h / 80 °C

3.3: 4 h / 80 °C

With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

(trans)-(4-hydroxy-cyclohexyl)-methyl-amine (164646-07-5) → pyridin-4-ylmethyl-carbamic acid 4-{[(pyrrolidine-1-carbonyl)-amino]-methyl}-cyclohexyl ester (1369590-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 20 °C

2.1: acetonitrile / 1 h / 80 °C

2.2: 1 h / 80 °C

2.3: 4 h / 80 °C

With triethylamine; In dichloromethane; acetonitrile;

upstream raw materials:

4-(aminomethyl)pyridine

pyrrolidine-1-carboxylic acid (4-hydroxy-cyclohexylmethyl)-amide

1,1'-carbonyldiimidazole

4-(hydroxymethyl)cyclohexan-1-ol