3-Methoxy-2-methyl-1,3-diphenylpropan-1-one

Base Information

• Chemical Name: 3-Methoxy-2-methyl-1,3-diphenylpropan-1-one
• CAS No.: 167990-19-4
• Molecular Formula: C17H18O2
• Molecular Weight: 254.329
• DSSTox Substance ID: DTXSID90502927
• Nikkaji Number: J536.155I
• Mol file: 167990-19-4.mol

Synonyms:3-methoxy-2-methyl-1,3-diphenylpropan-1-one;167990-19-4;SCHEMBL13900818;DTXSID90502927;3-methoxy-2-methyl-1,3-diphenyl-1-propanone

Chemical Property of 3-Methoxy-2-methyl-1,3-diphenylpropan-1-one

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 254.130679813
• Heavy Atom Count: 19
• Complexity: 275

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(C1=CC=CC=C1)OC)C(=O)C2=CC=CC=C2

Technology Process of 3-Methoxy-2-methyl-1,3-diphenylpropan-1-one

There total 5 articles about 3-Methoxy-2-methyl-1,3-diphenylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

benzaldehyde dimethyl acetal (1125-88-8) + 1-phenyl-propan-1-one (93-55-0) → anti-3-methoxy-2-methyl-1,3-diphenyl-1-propanone (167990-19-4)

Guidance literature:

1-phenyl-propan-1-one; With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃; for 0.5h;

benzaldehyde dimethyl acetal; In dichloromethane; at -78 ℃; for 0.5h;

DOI:10.1021/ol030108u

Reference yield: 90.0%

benzaldehyde dimethyl acetal (1125-88-8) + trimethyl[(Z)-(1-phenyl-1-propenyl)oxy]silane (66323-99-7) → anti-3-methoxy-2-methyl-1,3-diphenyl-1-propanone (167990-19-4)

Guidance literature:

chloro-trimethyl-silane; tin(ll) chloride; In dichloromethane; at -78 ℃; for 1.5h;

DOI:10.1246/cl.1987.463

Reference yield: 59.0%

benzyl methyl ether (538-86-3) + 1-phenyl-propan-1-one (93-55-0) → anti-3-methoxy-2-methyl-1,3-diphenyl-1-propanone (167990-19-4)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; at 100 ℃; for 2h;

DOI:10.1021/ja060050p

upstream raw materials:

benzaldehyde dimethyl acetal

trimethyl[(Z)-(1-phenyl-1-propenyl)oxy]silane

(2SR,3RS)-2-methyl-1,3-diphenyl-3-hydroxypropan-1-one

1-phenyl-propan-1-one