2-[Methyl(phenyl)amino]propan-1-ol

Base Information

• Chemical Name: 2-[Methyl(phenyl)amino]propan-1-ol
• CAS No.: 16955-19-4
• Molecular Formula: C10H15NO
• Molecular Weight: 165.235
• DSSTox Substance ID: DTXSID10499966
• Nikkaji Number: J1.037.547I
• Mol file: 16955-19-4.mol

Synonyms:16955-19-4;DTXSID10499966;2-[Methyl(phenyl)amino]propan-1-ol

Chemical Property of 2-[Methyl(phenyl)amino]propan-1-ol

Chemical Property:

• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 165.115364102
• Heavy Atom Count: 12
• Complexity: 121

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(CO)N(C)C1=CC=CC=C1

Technology Process of 2-[Methyl(phenyl)amino]propan-1-ol

There total 6 articles about 2-[Methyl(phenyl)amino]propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

carbon monoxide (201230-82-2) + N-(2-hydroxyethyl)-N-methylaminobenzene (93-90-3) → 2-(N-methyl-N-phenylamino)propan-1-ol (16955-19-4)

Guidance literature:

With [Mn(HN(C₂H₄PⁱPr₂)₂)(CO)₂Br]; hydrogen; sodium t-butanolate; In toluene; at 150 ℃; for 24h;

DOI:10.1039/d0sc05404f

Reference yield: 65.0%

methanol (67-56-1) + acetaldehyde (75-07-0,9002-91-9) + N-methylaniline (100-61-8) → 2-(N-methyl-N-phenylamino)propan-1-ol (16955-19-4)

Guidance literature:

With tert.-butylhydroperoxide; titanium(III) chloride; at 20 ℃; for 0.5h; Acidic aq. solution; Inert atmosphere;

DOI:10.1021/ol802244n

Reference yield:

N-(2-Methoxy-1-methylethyl)aniline (78923-90-7) → 2-(N-methyl-N-phenylamino)propan-1-ol (16955-19-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / triethylamine / CHCl₃ / 3 h / Heating

2: hydrochloric acid / H₂O / 6 h / 70 °C

3: sodium hydride

With hydrogenchloride; sodium hydride; triethylamine; In chloroform; water;

DOI:10.1016/S0040-4020(01)00285-X

upstream raw materials:

2-anilino-1-propanol

N-(2-Methoxy-1-methylethyl)aniline

N-(methoxyprop-2-yl)benzanilide

methanol