2-Propenoic acid, 3-amino-3-[5-benzoyl-4-hydroxy-2-[(2-oxo-2-phenylethyl)thio]-3-thienyl]- 2-cyano-, ethyl ester, (E)-

Base Information

• Chemical Name: 2-Propenoic acid, 3-amino-3-[5-benzoyl-4-hydroxy-2-[(2-oxo-2-phenylethyl)thio]-3-thienyl]- 2-cyano-, ethyl ester, (E)-
• CAS No.: 170377-18-1
• Molecular Formula: C₂₅H₂₀N₂O₅S₂
• Molecular Weight: 492.576
• Mol file: 170377-18-1.mol

Synonyms:

Chemical Property of 2-Propenoic acid, 3-amino-3-[5-benzoyl-4-hydroxy-2-[(2-oxo-2-phenylethyl)thio]-3-thienyl]- 2-cyano-, ethyl ester, (E)-

Chemical Property:

Purity/Quality:

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Technology Process of 2-Propenoic acid, 3-amino-3-[5-benzoyl-4-hydroxy-2-[(2-oxo-2-phenylethyl)thio]-3-thienyl]- 2-cyano-, ethyl ester, (E)-

There total 1 articles about 2-Propenoic acid, 3-amino-3-[5-benzoyl-4-hydroxy-2-[(2-oxo-2-phenylethyl)thio]-3-thienyl]- 2-cyano-, ethyl ester, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbon disulfide (75-15-0,12122-00-8) + diethyl 3-amino-2-cyano-2-pentene-1,5-dicarboxylate (89779-30-6) + α-bromoacetophenone (70-11-1) → Ethyl 3-amino-2-cyano-3-(5'-benzoyl-4'-hydroxy-2'-phenacylthio-3'-thienyl)acrylate (170377-18-1)

Guidance literature:

With potassium hydroxide; Yield given. Multistep reaction; 1.) DMF, r.t., 24 h, 2.) r.t., 24 h;

DOI:10.1007/BF00807435

Reference yield: 60.0%

phenylhydrazine (100-63-0) + Ethyl 3-amino-2-cyano-3-(5'-benzoyl-4'-hydroxy-2'-phenacylthio-3'-thienyl)acrylate (170377-18-1) → 6-Cyanoethoxycarbonylmethylidene-1,3,5-triphenyl-4H-thieno<4,5-c:2,3-c'>dipyrazole

Guidance literature:

In ethanol; for 6h; Heating;

DOI:10.1007/BF00807435

Reference yield: 55.0%

Benzoyl isothiocyanate (532-55-8) + Ethyl 3-amino-2-cyano-3-(5'-benzoyl-4'-hydroxy-2'-phenacylthio-3'-thienyl)acrylate (170377-18-1) → 6-Amino-1-benzoyl-4-(5'-benzoyl-4'-hydroxy-2'-phenacylthio-3'-thienyl)-5-ethoxycarbonylpyrimidine-2-thione

Guidance literature:

With triethylamine; In 1,4-dioxane; 1.) reflux, 4 h, 2.) r.t., overnight;

DOI:10.1007/BF00807435

upstream raw materials:

carbon disulfide

diethyl 3-amino-2-cyano-2-pentene-1,5-dicarboxylate

α-bromoacetophenone

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