4'-Chloro-2-hydroxy-4-methoxybenzophenone

Base Information

• Chemical Name: 4'-Chloro-2-hydroxy-4-methoxybenzophenone
• CAS No.: 85-28-9
• Molecular Formula: C14H11 Cl O3
• Molecular Weight: 262.693
• European Community (EC) Number: 201-595-1
• NSC Number: 56768
• UNII: 4F6ND79QPK
• DSSTox Substance ID: DTXSID20234047
• Nikkaji Number: J192.628D
• Wikidata: Q83115760
• Mol file: 85-28-9.mol

Synonyms:4'-Chloro-2-hydroxy-4-methoxybenzophenone;85-28-9;(4-chlorophenyl)-(2-hydroxy-4-methoxyphenyl)methanone;4F6ND79QPK;C14H11ClO3;Methanone, (4-chlorophenyl)(2-hydroxy-4-methoxyphenyl)-;4/'-Chloro-2-hydroxy-4-methoxybenzophenone;EINECS 201-595-1;NSC-56768;Methanone,(4-chlorophenyl)(2-hydroxy-4-methoxyphenyl)-;2-hydroxy-4-methoxy-4'-chlorobenzophenone;Benzophenone, 4'-chloro-2-hydroxy-4-methoxy-;NSC56768;UNII-4F6ND79QPK;NCIOpen2_002243;SCHEMBL1483827;DTXSID20234047;NSC 56768;AKOS024333023;4'-chlor-2-hydroxy-4-methoxybenzophenon;4'-chloro-2-hydroxy-4-methoxy-benzophenone;4-Chlorophenyl(2-hydroxy-4-methoxyphenyl) ketone;(4-Chlorophenyl)(2-hydroxy-4-methoxyphenyl)methanone

Chemical Property of 4'-Chloro-2-hydroxy-4-methoxybenzophenone

Chemical Property:

• XLogP3: 4.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 262.0396719
• Heavy Atom Count: 18
• Complexity: 287

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)C(=O)C2=CC=C(C=C2)Cl)O

Technology Process of 4'-Chloro-2-hydroxy-4-methoxybenzophenone

There total 2 articles about 4'-Chloro-2-hydroxy-4-methoxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-benzoyl chloride (122-01-0) + 1,3-Dimethoxybenzene (151-10-0) → 2-hydroxy-4-methoxy-4'-chlorobenzophenone (85-28-9) + 4-chloro-2',4'-dimethoxybenzophenone (57600-76-7)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 0 - 12 ℃; for 12h;

Reference yield:

→ 2-hydroxy-4-methoxy-4'-chlorobenzophenone (85-28-9)

Guidance literature:

Entspr.2-Phenyl-3-aryl-benzofuran, Oxid.;

Reference yield: 100.0%

2-hydroxy-4-methoxy-4'-chlorobenzophenone (85-28-9) + 4-chloro-2',4'-dimethoxybenzophenone (57600-76-7) → 2,4-dihydroxy-4'-chlorobenzophenone (18239-10-6)

Guidance literature:

With water; hydrogen bromide; acetic acid; at 90 ℃; for 12h;

upstream raw materials:

4-chloro-benzoyl chloride

1,3-Dimethoxybenzene

Downstream raw materials:

C₁₈H₁₈ClNO₄

E-4'-chloro-2-hydroxy-4-methoxybenzophenone oxime

4'-chloro-2-hydroxy-4-methoxy-benzophenone imine

2,4-dihydroxy-4'-chlorobenzophenone