4,4′-Dihydroxybenzophenone

Base Information

• Chemical Name: 4,4′-Dihydroxybenzophenone
• CAS No.: 18239-10-6
• Molecular Formula: C13H9ClO3
• Molecular Weight: 248.666
• Mol file: 18239-10-6.mol

Synonyms:Methanone, (4-chlorophenyl)(2,4-dihydroxyphenyl)-;2,4-Dihydroxy-4'-chlor-benzophenon;4'-chloro-2,4-dihydroxybenzophenone;4'-Chlor-2,4-dihydroxy-benzophenon;

Chemical Property of 4,4′-Dihydroxybenzophenone

Chemical Property:

• Melting Point: 151-152℃
• PSA: 57.53000
• Density: 1.409±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 2.98220

Purity/Quality:

99% ^*data from raw suppliers

(4-Chlorophenyl)(2,4-dihydroxyphenyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4′-Dihydroxybenzophenone

There total 8 articles about 4,4′-Dihydroxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-hydroxy-4-methoxy-4'-chlorobenzophenone (85-28-9) + 4-chloro-2',4'-dimethoxybenzophenone (57600-76-7) → 2,4-dihydroxy-4'-chlorobenzophenone (18239-10-6)

Guidance literature:

With water; hydrogen bromide; acetic acid; at 90 ℃; for 12h;

Reference yield:

4-chloro-benzoyl chloride (122-01-0) + recorcinol (108-46-3) → 2,4-dihydroxy-4'-chlorobenzophenone (18239-10-6)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; for 2h; Reflux; Inert atmosphere;

DOI:10.1080/14786419.2015.1041140

Reference yield:

1,3-Dimethoxybenzene (151-10-0) → 2,4-dihydroxy-4'-chlorobenzophenone (18239-10-6)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃ / nitrobenzene / 12 h / 50 °C

2: 7.0 g / aq. HBr; AcOH / 36 h / 120 °C

With aluminium trichloride; hydrogen bromide; acetic acid; In nitrobenzene; 1: Friedel-Crafts acylation;

DOI:10.1021/jm070638m

upstream raw materials:

recorcinol

para-chlorobenzoic acid

4-chloro-2',4'-dimethoxybenzophenone

4-chloro-benzoyl chloride

Downstream raw materials:

(4-(8-bromooctyloxy)-2-hydroxyphenyl)(4-chlorophenyl)methanone

4'-phenylthio-2,4-dihydroxybenzophenone

2-hydroxy-4-dodecyloxy-4'-phenylthiobenzophenone

2-Hydroxy-4-dodecyloxy-4'-chlorobenzophenone

Refernces

• 1、 Kurosu, Michio,Narayanasamy, Prabagaran,Biswas, Kallolmay,Dhiman, Rakesh,Crick, Dean C.. "Discovery of 1,4-didydroxy-2-naphthoate prenyltransferase inhibitors: New drug leads for multidrug-resistant gram-positive pathogens". . p. 3973 - 3975. Retrieved 2008/02/11.