3,3',4',7-Tetramethoxyflavone

Base Information

• Chemical Name: 3,3',4',7-Tetramethoxyflavone
• CAS No.: 17093-86-6
• Molecular Formula: C19H18O6
• Molecular Weight: 342.348
• Hs Code.: 2914509090
• Mol file: 17093-86-6.mol

Synonyms:fisetin tetramethyl ether;3,3',4',7-tetramethoxyflavone;2-(3,4-dimethoxyphenyl)-3,7-dimethoxy-4H-chromen-4-one;2-(3,4-dimethoxy-phenyl)-3,7-dimethoxy-chromen-4-one;3,7,3',4'-tetra-O-methylfisetin;3,3',4',7-tetra-O-methylfisetin;

Chemical Property of 3,3',4',7-Tetramethoxyflavone

Chemical Property:

• PSA: 67.13000
• LogP: 3.49440

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,3',4',7-Tetramethoxyflavone

There total 11 articles about 3,3',4',7-Tetramethoxyflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(3,4-dimethoxyphenyl)-3-hydroxy-7-methoxy-4H-chromen-4-one (58544-90-4) → 3,3',4',7-tetra-O-methylfisetin (17093-86-6)

Guidance literature:

2-(3,4-dimethoxyphenyl)-3-hydroxy-7-methoxy-4H-chromen-4-one; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

methyl halide; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2018.08.047

Reference yield: 71.0%

2-(3,4-dimethoxyphenyl)-3-hydroxy-7-methoxy-4H-chromen-4-one (58544-90-4) + methyl iodide (74-88-4) → 3,3',4',7-tetra-O-methylfisetin (17093-86-6)

Guidance literature:

With potassium carbonate; In acetone; for 24h; Reflux;

DOI:10.1016/j.ejmech.2013.06.035

Reference yield:

3,7,3',4'-tetrahydroxyflavone (528-48-3) + dimethyl sulfate (77-78-1) → 3,3',4',7-tetra-O-methylfisetin (17093-86-6)

Guidance literature:

With potassium carbonate;

DOI:10.1016/0031-9422(81)85114-X

upstream raw materials:

diazomethane

3,7,3',4'-tetrahydroxyflavone

dimethyl sulfate

methyl iodide

Downstream raw materials:

Veratric acid

Refernces

• 1、 Li, Xiang,Zhang, Changde,Guo, Shanchun,Rajaram, Pravien,Lee, Maizie,Chen, Guanglin,Fong, Ryan,Gonzalez, Aaron,Zhang, Qiang,Zheng, Shilong,Wang, Guangdi,Chen, Qiao-Hong. "Structure-activity relationship and pharmacokinetic studies of 3-O-substitutedflavonols as anti-prostate cancer agents". . p. 978 - 993. Retrieved 2018/09/05.
• 2、 Brandt, Edward W.,Ferreira, Daneel,Roux, David G.. "Metabolites from the Purple Heartwood of Mimosoideae. Part 3. Acacia crombei C.T. White: Structure and Partial Synthesis of Crombenin, A Natural Spiropeltogynoid". . p. 1879 - 1883. Retrieved 2007/10/02.