Propanedioic acid, [[bis(4-methoxyphenyl)phenylmethoxy]methyl][[[[bis(1-methylethyl)amino] (2-cyanoethoxy)phosphino]oxy]methyl]-, diethyl ester

Base Information

• Chemical Name: Propanedioic acid, [[bis(4-methoxyphenyl)phenylmethoxy]methyl][[[[bis(1-methylethyl)amino] (2-cyanoethoxy)phosphino]oxy]methyl]-, diethyl ester
• CAS No.: 171285-25-9
• Molecular Formula: C39H51N2O9P
• Molecular Weight: 722.816
• Mol file: 171285-25-9.mol

Synonyms:

Chemical Property of Propanedioic acid, [[bis(4-methoxyphenyl)phenylmethoxy]methyl][[[[bis(1-methylethyl)amino] (2-cyanoethoxy)phosphino]oxy]methyl]-, diethyl ester

Chemical Property:

Purity/Quality:

≥97% by HPLC ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanedioic acid, [[bis(4-methoxyphenyl)phenylmethoxy]methyl][[[[bis(1-methylethyl)amino] (2-cyanoethoxy)phosphino]oxy]methyl]-, diethyl ester

There total 3 articles about Propanedioic acid, [[bis(4-methoxyphenyl)phenylmethoxy]methyl][[[[bis(1-methylethyl)amino] (2-cyanoethoxy)phosphino]oxy]methyl]-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) + diethyl 2-hydroxymethyl-2-(4,4'-dimethoxytrityloxymethyl)malonate (171285-26-0) → (2-cyanoethyl) <2,2-bis(ethoxycarbonyl)-3-(4,4'-dimethoxytrityloxy)propyl-1> N,N-diisopropylphosphoramidite (171285-25-9)

Guidance literature:

With 1H-tetrazole; In acetonitrile; for 0.333333h; Ambient temperature;

DOI:10.1016/0040-4020(95)00544-I

Reference yield:

diethyl malonate (105-53-3) → (2-cyanoethyl) <2,2-bis(ethoxycarbonyl)-3-(4,4'-dimethoxytrityloxy)propyl-1> N,N-diisopropylphosphoramidite (171285-25-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N

2: 1.) Py, 2.) 1H-tetrazole

With pyridine; 1H-tetrazole; triethylamine;

Reference yield:

diethyl bis(hydroxymethyl)malonate (20605-01-0) + 4,4'-dimethoxytrityl chloride (40615-36-9) + N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) → (2-cyanoethyl) <2,2-bis(ethoxycarbonyl)-3-(4,4'-dimethoxytrityloxy)propyl-1> N,N-diisopropylphosphoramidite (171285-25-9)

Guidance literature:

With pyridine; 1H-tetrazole; Multistep reaction;

upstream raw materials:

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

diethyl 2-hydroxymethyl-2-(4,4'-dimethoxytrityloxymethyl)malonate

diethyl bis(hydroxymethyl)malonate

4,4'-dimethoxytrityl chloride