3,4-Dihydro-9-phenyl-1(2H)-acridinone

Base Information

• Chemical Name: 3,4-Dihydro-9-phenyl-1(2H)-acridinone
• CAS No.: 17401-27-3
• Molecular Formula: C19H15NO
• Molecular Weight: 273.334
• Hs Code.: 2933990090
• Mol file: 17401-27-3.mol

Synonyms:9-phenyl-3,4-dihydro-2H-acridin-1-one;

Chemical Property of 3,4-Dihydro-9-phenyl-1(2H)-acridinone

Chemical Property:

• PSA: 29.96000
• LogP: 4.42080

Purity/Quality:

97% ^*data from raw suppliers

3,4-Dihydro-9-phenyl-1(2H)-acridinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,4-Dihydro-9-phenyl-1(2H)-acridinone is used in the Friedlander synthesis of quinolines.

Technology Process of 3,4-Dihydro-9-phenyl-1(2H)-acridinone

There total 5 articles about 3,4-Dihydro-9-phenyl-1(2H)-acridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,3-cylohexanedione (504-02-9) + (2-aminophenyl)(phenyl)methanone (2835-77-0) → 9-phenyl-3,4-dihydro-2H-acridin-1-one (17401-27-3)

Guidance literature:

With o-benzenedisulfonimide; at 80 ℃; for 4h; Neat (no solvent);

DOI:10.1016/j.tetlet.2010.02.139

Reference yield: 91.0%

o-bromobenzophenone (13047-06-8) + 1,3-cylohexanedione (504-02-9) → 9-phenyl-3,4-dihydro-2H-acridin-1-one (17401-27-3)

Guidance literature:

With D-glucose; copper(II) sulfate; L-proline; potassium hydroxide; In ethanol; water; at 90 ℃; for 4h;

DOI:10.1039/c4ra14138e

Reference yield: 68.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + (2-aminophenyl)(phenyl)methanone (2835-77-0) → 9-phenyl-3,4-dihydro-2H-acridin-1-one (17401-27-3)

Guidance literature:

With Cu(II) decorated on isoniazid functionalized silica coated Fe₃O₄ magnetic nanoparticles; In ethanol; at 60 ℃; for 2h;

DOI:10.1016/j.poly.2019.114148

upstream raw materials:

1,3-cylohexanedione

(2-aminophenyl)(phenyl)methanone

o-bromobenzophenone

cyclohexenone

Refernces

• 1、 Satheeshkumar, Rajendran,Shanmugaraj, Krishnamoorthy,Delgado, Thalia,Bertrand, Jeanluc,Brito, Iván,Salas, Cristian O.. "Friedl?nder Synthesis of Novel Polycyclic Quinolines Using Solid SiO2/H2SO4 Catalyst". . p. 138 - 144. Retrieved 2021.
• 2、 Chaturbhuj, Ganesh U.,Mali, Anil S.,Sharma, Abhishek B.. "Sulfated Polyborate Catalyzed Selective Friedlander Annulation for Synthesis of Highly Functionalized Quinolines". . p. 1 - 7. Retrieved 2020/07/21.