1-(3-amino-5-nitro-phenyl)ethanone

Base Information

• Chemical Name: 1-(3-amino-5-nitro-phenyl)ethanone
• CAS No.: 5456-49-5
• Molecular Formula: C8H8 N2 O3
• Molecular Weight: 180.16
• Hs Code.: 2922399090
• Mol file: 5456-49-5.mol

Synonyms:Acetophenone,3'-amino-5'-nitro- (7CI,8CI); NSC 21476

Chemical Property of 1-(3-amino-5-nitro-phenyl)ethanone

Chemical Property:

• Vapor Pressure: 4.29E-05mmHg at 25°C
• Boiling Point: 350.8°C at 760 mmHg
• Flash Point: 166°C
• PSA: 88.91000
• Density: 1.333g/cm³
• LogP: 2.48400

Purity/Quality:

1-(3-Amino-5-nitrophenyl)ethanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-amino-5-nitro-phenyl)ethanone

There total 6 articles about 1-(3-amino-5-nitro-phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

acetyl chloride (75-36-5) + 3-nitro-aniline (99-09-2) → 1-(3-amino-5-nitrophenyl)ethanone (5456-49-5)

Guidance literature:

With zinc; at 52 - 54 ℃; for 0.00555556h; microwave irradiation;

DOI:10.1055/s-2003-42485

Reference yield:

1-(3,5-dinitrophenyl)ethanone (14401-75-3) + sodium hydrogencarbonate (144-55-8) → 1-(3-amino-5-nitrophenyl)ethanone (5456-49-5)

Guidance literature:

With stannous chloride; In hydrogenchloride; acetic acid;

Reference yield:

1-(3-bromo-5-nitrophenyl)ethanone (127413-59-6) → 1-(3-amino-5-nitrophenyl)ethanone (5456-49-5)

Guidance literature:

1-(3-bromo-5-nitrophenyl)ethanone; With copper(l) iodide; tert-butyl carbazate; potassium carbonate; N,N`-dimethylethylenediamine; In toluene; at 110 ℃;

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jm501504k

upstream raw materials:

1-(3,5-dinitrophenyl)ethanone

acetyl chloride

3-nitro-aniline

sodium hydrogencarbonate

Downstream raw materials:

1-(3-hydroxy-5-nitrophenyl)ethanone