4-(4-Methoxybenzyl)morpholine

Base Information

• Chemical Name: 4-(4-Methoxybenzyl)morpholine
• CAS No.: 17494-29-0
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.272
• DSSTox Substance ID: DTXSID50354803
• Nikkaji Number: J402.558J
• Wikidata: Q82133233
• ChEMBL ID: CHEMBL1392074
• Mol file: 17494-29-0.mol

Synonyms:4-(4-methoxybenzyl)morpholine;4-[(4-methoxyphenyl)methyl]morpholine;17494-29-0;Morpholine, 4-[(4-methoxyphenyl)methyl]-;HMS2176H19;SMR000137501;Cambridge id 5421516;Oprea1_181784;MLS000532562;SCHEMBL5755331;CHEMBL1392074;DTXSID50354803;STK103165;AKOS005397301;AB00084672-01;SR-01000208528;SR-01000208528-1

Chemical Property of 4-(4-Methoxybenzyl)morpholine

Chemical Property:

• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 207.125928785
• Heavy Atom Count: 15
• Complexity: 173

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CN2CCOCC2

Technology Process of 4-(4-Methoxybenzyl)morpholine

There total 33 articles about 4-(4-Methoxybenzyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-morpholinecarboxaldehyde (4394-85-8) + p-methoxybenzyl chloride (824-94-2) → 4-(4-methoxy-benzyl)-morpholine (17494-29-0)

Guidance literature:

With NHC-Pd(II)-Im; sodium hydroxide; In water; at 50 ℃; for 3h; Inert atmosphere; Schlenk technique;

DOI:10.3184/174751913X13787959859344

Reference yield: 98.0%

morpholine (110-91-8,99108-56-2) + p-methoxybenzyl chloride (824-94-2) → 4-(4-methoxy-benzyl)-morpholine (17494-29-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; for 6h; Reflux;

DOI:10.1021/acs.joc.8b02564

Reference yield: 95.0%

morpholine (110-91-8,99108-56-2) + 4-methoxy-benzaldehyde (123-11-5) → 4-(4-methoxy-benzyl)-morpholine (17494-29-0)

Guidance literature:

morpholine; 4-methoxy-benzaldehyde; at 30 ℃; for 1h;

With sodium tetrahydroborate; at 30 ℃; for 2h; Further stages.;

DOI:10.1016/j.tetlet.2007.10.094

upstream raw materials:

N-(ethoxymethyl)morpholine

(4-methoxyphenyl)trimethylstannane

(p-methoxyphenyl)tri-n-butylstannane

4-(morpholinomethyl)morpholine

Downstream raw materials:

2-Methoxy-5-(4-morpholinylmethyl)benzenemethanol

3-[[2-methoxy-5-(4-morpholinylmethyl)phenyl]methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-(3H)-one

4-(p-methoxybenzyl)morpholin-3-one