3-Cinnolinecarboxylic acid, 4-hydroxy-, methyl ester

Base Information

Chemical Name:3-Cinnolinecarboxylic acid, 4-hydroxy-, methyl ester
CAS No.:17762-13-9
Molecular Formula:C₁₀H₈N₂O₃
Molecular Weight:204.185
Hs Code.:

Synonyms:4-Hydroxy-cinnoline-3-carboxylic acid;methyl 4-hydroxycinnoline-3-carboxylate;4-oxo-1,4-dihydro-cinnoline-3-carboxylic acid methyl ester;4-Hydroxy-cinnoline-3-carboxylic acid,methyl ester;4-Hydroxy-cinnolin-3-carbonsaeuremethylester;3-Cinnolinecarboxylic acid,4-hydroxy-,methyl ester;

Suppliers and Price of 3-Cinnolinecarboxylic acid, 4-hydroxy-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
methyl4-hydroxycinnoline-3-carboxylate
50mg
$ 110.00

AccelPharmtech
4-hydroxy-3-Cinnolinecarboxylicacidmethylester 97.00%
25G
$ 8510.00

Total 1 raw suppliers

Chemical Property of 3-Cinnolinecarboxylic acid, 4-hydroxy-, methyl ester

Chemical Property:

PSA：72.31000
LogP:1.12200

Purity/Quality:: methyl4-hydroxycinnoline-3-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Cinnolinecarboxylic acid, 4-hydroxy-, methyl ester

There total 4 articles about 3-Cinnolinecarboxylic acid, 4-hydroxy-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 67-56-1
methanol

: 17762-13-9
methyl 4-hydroxylcinnoline-3-carboxylate

Guidance literature:: 2-(phenylhydrazono)-propanedioyl dichloride; With titanium tetrachloride; In 1,2-dichloro-ethane; Heating / reflux;

methanol; In 1,2-dichloro-ethane; for 0.5h;

Reference yield:

: 67-56-1
methanol

: 19288-90-5
2-(phenylhydrazono)-propanedioyl dichloride

: 17762-13-9
methyl 4-hydroxylcinnoline-3-carboxylate

Guidance literature:: 2-(phenylhydrazono)-propanedioyl dichloride; With titanium tetrachloride; In 1,2-dichloro-ethane; at 110 ℃; for 4h; Inert atmosphere;

methanol; In 1,2-dichloro-ethane; at 60 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.9b00858

Reference yield:

: 40885-82-3
2-(phenylhydrazono)malonic acid

: 17762-13-9
methyl 4-hydroxylcinnoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / chloroform / 2 h / 80 °C / Inert atmosphere

2.1: titanium tetrachloride / 1,2-dichloro-ethane / 4 h / 110 °C / Inert atmosphere

2.2: 0.5 h / 60 °C / Inert atmosphere

With thionyl chloride; titanium tetrachloride; In chloroform; 1,2-dichloro-ethane;
DOI:10.1021/acs.jmedchem.9b00858