(1Z)-1-{[2-(5-phenyl-1,2,4-triazin-3-yl)hydrazino]methylidene}naphthalen-2(1H)-one

Base Information

• Chemical Name: (1Z)-1-{[2-(5-phenyl-1,2,4-triazin-3-yl)hydrazino]methylidene}naphthalen-2(1H)-one
• CAS No.: 5661-48-3
• Molecular Formula: C10H13 N O3 S
• Molecular Weight: 341.366
• Mol file: 5661-48-3.mol

Synonyms:Acetamide,N-[p-(methylsulfonyl)benzyl]- (6CI,8CI); Sulfone, p-(acetamidomethyl)phenylmethyl

Chemical Property of (1Z)-1-{[2-(5-phenyl-1,2,4-triazin-3-yl)hydrazino]methylidene}naphthalen-2(1H)-one

Chemical Property:

• Vapor Pressure: 6.15E-16mmHg at 25°C
• Boiling Point: 633.2°C at 760 mmHg
• Flash Point: 336.7°C
• Density: 1.396g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1Z)-1-{[2-(5-phenyl-1,2,4-triazin-3-yl)hydrazino]methylidene}naphthalen-2(1H)-one

There total 4 articles about (1Z)-1-{[2-(5-phenyl-1,2,4-triazin-3-yl)hydrazino]methylidene}naphthalen-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

hydrogen cyanide (74-90-8) + 4-methylsulfonylbenzoic acid (4052-30-6) → N-(4-methanesulfonyl-benzyl)-acetamide (5661-48-3)

Guidance literature:

With iodobenzene; water; toluene-4-sulfonic acid; Selectfluor; at 25 ℃; for 16h; Irradiation; Inert atmosphere;

DOI:10.1021/acscatal.1c05077

Reference yield:

p-methanesulfonylbenzyl amine (4393-16-2) + acetic acid (64-19-7,77671-22-8) → N-(4-methanesulfonyl-benzyl)-acetamide (5661-48-3)

Guidance literature:

at 160 ℃;

Reference yield:

4-(acetamidomethyl)benzene-1-sulfonyl chloride (28073-51-0) → N-(4-methanesulfonyl-benzyl)-acetamide (5661-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1: alkaline aqueous sodium sulfite

2: aq. NaOH solution

With sodium hydroxide; alkaline aqueous sodium sulfite;

upstream raw materials:

p-methanesulfonylbenzyl amine

acetic acid

4-(acetylamino-methyl)-benzenesulfinic acid

methyl iodide

Downstream raw materials:

p-methanesulfonylbenzyl amine

N-(4-methanesulfonyl-benzyl)-diacetamide