2H-Pyran-4-methanol, 4-(3-fluoro-5-hydroxyphenyl)tetrahydro-a-methyl-

Base Information

Chemical Name:2H-Pyran-4-methanol, 4-(3-fluoro-5-hydroxyphenyl)tetrahydro-a-methyl-
CAS No.:179420-71-4
Molecular Formula:C13H17FO3
Molecular Weight:240.275
Hs Code.:

Synonyms:

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Chemical Property of 2H-Pyran-4-methanol, 4-(3-fluoro-5-hydroxyphenyl)tetrahydro-a-methyl-

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Technology Process of 2H-Pyran-4-methanol, 4-(3-fluoro-5-hydroxyphenyl)tetrahydro-a-methyl-

There total 7 articles about 2H-Pyran-4-methanol, 4-(3-fluoro-5-hydroxyphenyl)tetrahydro-a-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 130722-44-0
5-benzyloxy-3-fluorophenyl bromide

: 179420-71-4
4-(1-hydroxyethyl)-4-(3-fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaH / dioxane / 0 °C

1.2: 34 percent / CuBr / dioxane / 4.5 h / Heating

2.1: aq. LiCl / dimethylsulfoxide / 5 °C / Heating

3.1: NaH; 15-crown-5 / dimethylformamide / 0.42 h / 20 °C

3.2: 58 percent / NaI / dimethylformamide / 24 h / 20 °C

4.1: 94 percent / LiAlH₄ / diethyl ether / 0.33 h / 20 °C

5.1: 86 percent / tetra-n-propylammonium perruthenate; N-methylmorpholine N-oxide; 3 A molecular sieves / 0.83 h / 20 °C

6.1: 63 percent / tetrahydrofuran / 20 °C

7.1: H₂ / Pd/C / ethanol

With lithium aluminium tetrahydride; tetrapropylammonium perruthennate; 15-crown-5; 3 A molecular sieve; hydrogen; sodium hydride; 4-methylmorpholine N-oxide; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm0303554

Reference yield:

: 179420-65-6
ethyl 3-benzyloxy-5-fluorophenylacetate

: 179420-71-4
4-(1-hydroxyethyl)-4-(3-fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH; 15-crown-5 / dimethylformamide / 0.42 h / 20 °C

1.2: 58 percent / NaI / dimethylformamide / 24 h / 20 °C

2.1: 94 percent / LiAlH₄ / diethyl ether / 0.33 h / 20 °C

3.1: 86 percent / tetra-n-propylammonium perruthenate; N-methylmorpholine N-oxide; 3 A molecular sieves / 0.83 h / 20 °C

4.1: 63 percent / tetrahydrofuran / 20 °C

5.1: H₂ / Pd/C / ethanol

With lithium aluminium tetrahydride; tetrapropylammonium perruthennate; 15-crown-5; 3 A molecular sieve; hydrogen; sodium hydride; 4-methylmorpholine N-oxide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0303554

Reference yield:

: 179420-69-0
4-formyl-4-[5-(benzyloxy)-3-fluorophenyl]-3,4,5,6-tetrahydro-2H-pyran

: 179420-71-4
4-(1-hydroxyethyl)-4-(3-fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / tetrahydrofuran / 20 °C

2: H₂ / Pd/C / ethanol

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm0303554