Ethanone, 1-[4-(3-fluoro-5-hydroxyphenyl)tetrahydro-2H-pyran-4-yl]-

Base Information

Chemical Name:Ethanone, 1-[4-(3-fluoro-5-hydroxyphenyl)tetrahydro-2H-pyran-4-yl]-
CAS No.:179420-72-5
Molecular Formula:C13H15FO3
Molecular Weight:238.259
Hs Code.:

Synonyms:

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Chemical Property of Ethanone, 1-[4-(3-fluoro-5-hydroxyphenyl)tetrahydro-2H-pyran-4-yl]-

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Technology Process of Ethanone, 1-[4-(3-fluoro-5-hydroxyphenyl)tetrahydro-2H-pyran-4-yl]-

There total 9 articles about Ethanone, 1-[4-(3-fluoro-5-hydroxyphenyl)tetrahydro-2H-pyran-4-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 130722-44-0
5-benzyloxy-3-fluorophenyl bromide

: 179420-72-5
4-Acetyl-4-(3-fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 8 steps

1.1: NaH / dioxane / 0 °C

1.2: 34 percent / CuBr / dioxane / 4.5 h / Heating

2.1: aq. LiCl / dimethylsulfoxide / 5 °C / Heating

3.1: NaH; 15-crown-5 / dimethylformamide / 0.42 h / 20 °C

3.2: 58 percent / NaI / dimethylformamide / 24 h / 20 °C

4.1: 94 percent / LiAlH₄ / diethyl ether / 0.33 h / 20 °C

5.1: 86 percent / tetra-n-propylammonium perruthenate; N-methylmorpholine N-oxide; 3 A molecular sieves / 0.83 h / 20 °C

6.1: 63 percent / tetrahydrofuran / 20 °C

7.1: H₂ / Pd/C / ethanol

8.1: tetra-n-propylammonium perruthenate; N-methylmorpholine N-oxide; 3 A molecular sieves / 20 °C

With lithium aluminium tetrahydride; tetrapropylammonium perruthennate; 15-crown-5; 3 A molecular sieve; hydrogen; sodium hydride; 4-methylmorpholine N-oxide; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm0303554

Reference yield:

: 179420-65-6
ethyl 3-benzyloxy-5-fluorophenylacetate

: 179420-72-5
4-Acetyl-4-(3-fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH; 15-crown-5 / dimethylformamide / 0.42 h / 20 °C

1.2: 58 percent / NaI / dimethylformamide / 24 h / 20 °C

2.1: 94 percent / LiAlH₄ / diethyl ether / 0.33 h / 20 °C

3.1: 86 percent / tetra-n-propylammonium perruthenate; N-methylmorpholine N-oxide; 3 A molecular sieves / 0.83 h / 20 °C

4.1: 63 percent / tetrahydrofuran / 20 °C

5.1: H₂ / Pd/C / ethanol

6.1: tetra-n-propylammonium perruthenate; N-methylmorpholine N-oxide; 3 A molecular sieves / 20 °C

With lithium aluminium tetrahydride; tetrapropylammonium perruthennate; 15-crown-5; 3 A molecular sieve; hydrogen; sodium hydride; 4-methylmorpholine N-oxide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0303554

Reference yield:

: 179420-68-9
4-hydroxymethyl-4-(5-benzyloxy-3-fluorophenyl)-3,4,5,6-tetrahydro-2H-pyran

: 179420-72-5
4-Acetyl-4-(3-fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / tetra-n-propylammonium perruthenate; N-methylmorpholine N-oxide; 3 A molecular sieves / 0.83 h / 20 °C

2: 63 percent / tetrahydrofuran / 20 °C

3: H₂ / Pd/C / ethanol

4: tetra-n-propylammonium perruthenate; N-methylmorpholine N-oxide; 3 A molecular sieves / 20 °C

With tetrapropylammonium perruthennate; 3 A molecular sieve; hydrogen; 4-methylmorpholine N-oxide; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm0303554