1-Piperidinecarboxylic acid, 4-[4-[[(7-cyano-2-naphthalenyl)methyl][(ethylamino)carbonyl]amino]phen oxy]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-[4-[[(7-cyano-2-naphthalenyl)methyl][(ethylamino)carbonyl]amino]phen oxy]-, 1,1-dimethylethyl ester
CAS No.:179756-05-9
Molecular Formula:C31H36N4O4
Molecular Weight:528.651
Hs Code.:
Mol file:179756-05-9.mol

1-Piperidinecarboxylic acid,
4-[4-[[(7-cyano-2-naphthalenyl)methyl][(ethylamino)carbonyl]amino]phen
oxy]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of 1-Piperidinecarboxylic acid, 4-[4-[[(7-cyano-2-naphthalenyl)methyl][(ethylamino)carbonyl]amino]phen oxy]-, 1,1-dimethylethyl ester

Chemical Property:

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Technology Process of 1-Piperidinecarboxylic acid, 4-[4-[[(7-cyano-2-naphthalenyl)methyl][(ethylamino)carbonyl]amino]phen oxy]-, 1,1-dimethylethyl ester

There total 5 articles about 1-Piperidinecarboxylic acid, 4-[4-[[(7-cyano-2-naphthalenyl)methyl][(ethylamino)carbonyl]amino]phen oxy]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 109-90-0
ethyl isocyanate

: 179755-93-2
7-({4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-anilino}methyl)naphthalene-2-carbonitrile

: 179756-05-9
1-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-1-[(7-cyano-2-naphthyl)methyl]-3-ethylurea

Guidance literature:: In dichloromethane; at 20 ℃; for 21h;
DOI:10.1016/S0968-0896(01)00418-7

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 179756-05-9
1-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-1-[(7-cyano-2-naphthyl)methyl]-3-ethylurea

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / Ph₃P; DEAD / tetrahydrofuran / 21 h / 20 °C

2: 98 percent / H₂ / 10 percent Pd/C / ethanol / 15 h / 20 °C

3: 79 percent / NaB(OAc)3H / CH₂Cl₂; acetic acid / 0.75 h / 20 °C

4: 88 percent / CH₂Cl₂ / 21 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; 1: Mitsunobu condensation;
DOI:10.1016/S0968-0896(01)00418-7

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 179756-05-9
1-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-1-[(7-cyano-2-naphthyl)methyl]-3-ethylurea

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / Ph₃P; DEAD / tetrahydrofuran / 21 h / 20 °C

2: 98 percent / H₂ / 10 percent Pd/C / ethanol / 15 h / 20 °C

3: 79 percent / NaB(OAc)3H / CH₂Cl₂; acetic acid / 0.75 h / 20 °C

4: 88 percent / CH₂Cl₂ / 21 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; 1: Mitsunobu condensation;
DOI:10.1016/S0968-0896(01)00418-7