Ethyl 4-ethyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

Chemical Name:Ethyl 4-ethyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS No.:17994-57-9
Molecular Formula:C10H16N2O3
Molecular Weight:212.249
Hs Code.:2933599090
DSSTox Substance ID:DTXSID30571910
Nikkaji Number:J1.186.856H
Mol file:17994-57-9.mol

Synonyms:ETHYL 4-ETHYL-6-METHYL-2-OXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE;17994-57-9;ethyl 4-ethyl-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate;SCHEMBL17367946;DTXSID30571910

Suppliers and Price of Ethyl 4-ethyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of Ethyl 4-ethyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Chemical Property:

PSA：70.92000
LogP:0.88370
XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:212.11609238
Heavy Atom Count:15
Complexity:310

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC1C(=C(NC(=O)N1)C)C(=O)OCC

Technology Process of Ethyl 4-ethyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 5 articles about Ethyl 4-ethyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 141-97-9
ethyl acetoacetate

: 123-38-6
propionaldehyde

: 57-13-6
urea

: 17994-57-9
5-ethoxycarbonyl-4-ethyl-6-methyl-3,4-dihydro-pyrimidin-2(1H)-one

Guidance literature:: With TS-1 zeolite; at 50 ℃; for 0.2h; Neat (no solvent);
DOI:10.3762/bjoc.5.4

Reference yield: 93.0%

: 17994-57-9
5-ethoxycarbonyl-4-ethyl-6-methyl-3,4-dihydro-pyrimidin-2(1H)-one

Guidance literature:: With hydrogenchloride; In ethanol; water; for 5h; Reagent/catalyst; Solvent; Reflux;

Reference yield: 88.0%

: 74-96-4
ethyl bromide

: 6214-64-8
6-methyl-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid ethyl ester

: 17994-57-9
5-ethoxycarbonyl-4-ethyl-6-methyl-3,4-dihydro-pyrimidin-2(1H)-one

Guidance literature:: ethyl bromide; With magnesium; In diethyl ether; Inert atmosphere;

6-methyl-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid ethyl ester; In tetrahydrofuran; diethyl ether; at -78 ℃; chemoselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.200900208