Benzenemethanol, 6-[2-(7,7-dimethyl-1,4-dioxaspiro[4.5]dec-6-yl)ethyl]-2,3-dimethoxy-4-(1 -methylethyl)-

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Chemical Name:Benzenemethanol, 6-[2-(7,7-dimethyl-1,4-dioxaspiro[4.5]dec-6-yl)ethyl]-2,3-dimethoxy-4-(1 -methylethyl)-
CAS No.:181016-83-1
Molecular Formula:C24H38O5
Molecular Weight:406.563
Hs Code.:
Mol file:181016-83-1.mol

Synonyms:

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Chemical Property of Benzenemethanol, 6-[2-(7,7-dimethyl-1,4-dioxaspiro[4.5]dec-6-yl)ethyl]-2,3-dimethoxy-4-(1 -methylethyl)-

Chemical Property:

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Technology Process of Benzenemethanol, 6-[2-(7,7-dimethyl-1,4-dioxaspiro[4.5]dec-6-yl)ethyl]-2,3-dimethoxy-4-(1 -methylethyl)-

There total 13 articles about Benzenemethanol, 6-[2-(7,7-dimethyl-1,4-dioxaspiro[4.5]dec-6-yl)ethyl]-2,3-dimethoxy-4-(1 -methylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 181016-83-1
{6-[2-(7,7-Dimethyl-1,4-dioxa-spiro[4.5]dec-6-yl)-ethyl]-4-isopropyl-2,3-dimethoxy-phenyl}-methanol

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) n-BuLi / 1.) THF, RT, 3 h, 2.) THF, -78 deg C, 2 h

2: 90 percent / AcONa, Br₂ / acetic acid / Ambient temperature

3: 98 percent / diethyl ether / Heating

4: 95 percent / p-TsOH / benzene / Heating

5: 1.) n-BuLi / 1.) THF, from -78 deg C to RT, 4.5 h, 2.) THF, Et₂O, from -78 deg C to RT, 6 h

6: 99 percent / H₂ / 10percent Pd/C / ethanol / Ambient temperature

7: 100 percent / PPh₃, imidazole, I₂ / acetonitrile; diethyl ether / 1 h

8: 1.) LDA / 1.) THF, a) -78 deg C, 1 h, b) RT, 2 h, 2.) THF, a) -78 deg C, 3 h, b) RT, 24 h

9: 91 percent / Li, liquid NH₃ / diethyl ether / 2 h

10: 84 percent / BF₃*Et₂O / diethyl ether / 24 h / Ambient temperature

11: 1.) n-BuLi / 1.) THF, Et₂O, RT, 5 h, 2.) THF, Et₂O, a) -20 deg C, 2 h, b) RT, overnight

With 1H-imidazole; n-butyllithium; boron trifluoride diethyl etherate; ammonia; hydrogen; bromine; iodine; sodium acetate; lithium; toluene-4-sulfonic acid; triphenylphosphine; lithium diisopropyl amide; palladium on activated charcoal; In diethyl ether; ethanol; acetic acid; acetonitrile; benzene;
DOI:10.1016/0040-4020(96)00604-7

Reference yield:

: 91971-58-3
ethyl 2,3-dimethoxy benzoate

: 181016-83-1
{6-[2-(7,7-Dimethyl-1,4-dioxa-spiro[4.5]dec-6-yl)-ethyl]-4-isopropyl-2,3-dimethoxy-phenyl}-methanol

Guidance literature:: Multi-step reaction with 10 steps

1: 90 percent / AcONa, Br₂ / acetic acid / Ambient temperature

2: 98 percent / diethyl ether / Heating

3: 95 percent / p-TsOH / benzene / Heating

4: 1.) n-BuLi / 1.) THF, from -78 deg C to RT, 4.5 h, 2.) THF, Et₂O, from -78 deg C to RT, 6 h

5: 99 percent / H₂ / 10percent Pd/C / ethanol / Ambient temperature

6: 100 percent / PPh₃, imidazole, I₂ / acetonitrile; diethyl ether / 1 h

7: 1.) LDA / 1.) THF, a) -78 deg C, 1 h, b) RT, 2 h, 2.) THF, a) -78 deg C, 3 h, b) RT, 24 h

8: 91 percent / Li, liquid NH₃ / diethyl ether / 2 h

9: 84 percent / BF₃*Et₂O / diethyl ether / 24 h / Ambient temperature

10: 1.) n-BuLi / 1.) THF, Et₂O, RT, 5 h, 2.) THF, Et₂O, a) -20 deg C, 2 h, b) RT, overnight

With 1H-imidazole; n-butyllithium; boron trifluoride diethyl etherate; ammonia; hydrogen; bromine; iodine; sodium acetate; lithium; toluene-4-sulfonic acid; triphenylphosphine; lithium diisopropyl amide; palladium on activated charcoal; In diethyl ether; ethanol; acetic acid; acetonitrile; benzene;
DOI:10.1016/0040-4020(96)00604-7

Reference yield:

: 181016-78-4
5-bromo-1-isopropenyl-2,3-dimethoxybenzene

: 181016-83-1
{6-[2-(7,7-Dimethyl-1,4-dioxa-spiro[4.5]dec-6-yl)-ethyl]-4-isopropyl-2,3-dimethoxy-phenyl}-methanol

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) n-BuLi / 1.) THF, from -78 deg C to RT, 4.5 h, 2.) THF, Et₂O, from -78 deg C to RT, 6 h

2: 99 percent / H₂ / 10percent Pd/C / ethanol / Ambient temperature

3: 100 percent / PPh₃, imidazole, I₂ / acetonitrile; diethyl ether / 1 h

4: 1.) LDA / 1.) THF, a) -78 deg C, 1 h, b) RT, 2 h, 2.) THF, a) -78 deg C, 3 h, b) RT, 24 h

5: 91 percent / Li, liquid NH₃ / diethyl ether / 2 h

6: 84 percent / BF₃*Et₂O / diethyl ether / 24 h / Ambient temperature

7: 1.) n-BuLi / 1.) THF, Et₂O, RT, 5 h, 2.) THF, Et₂O, a) -20 deg C, 2 h, b) RT, overnight

With 1H-imidazole; n-butyllithium; boron trifluoride diethyl etherate; ammonia; hydrogen; iodine; lithium; triphenylphosphine; lithium diisopropyl amide; palladium on activated charcoal; In diethyl ether; ethanol; acetonitrile;
DOI:10.1016/0040-4020(96)00604-7