(3S)-3-Methyl-1-(phenylmethoxy)-2,5-pyrrolidinedione

Base Information

Chemical Name:(3S)-3-Methyl-1-(phenylmethoxy)-2,5-pyrrolidinedione
CAS No.:182007-76-7
Molecular Formula:C12H13NO3
Molecular Weight:219.24
Hs Code.:
DSSTox Substance ID:DTXSID301216865
Nikkaji Number:J983.469I

Synonyms:SCHEMBL4179162;DTXSID301216865;182007-76-7;(3S)-3-Methyl-1-(phenylmethoxy)-2,5-pyrrolidinedione

Suppliers and Price of (3S)-3-Methyl-1-(phenylmethoxy)-2,5-pyrrolidinedione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of (3S)-3-Methyl-1-(phenylmethoxy)-2,5-pyrrolidinedione

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:219.08954328
Heavy Atom Count:16
Complexity:284

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1CC(=O)N(C1=O)OCC2=CC=CC=C2
Isomeric SMILES:C[C@H]1CC(=O)N(C1=O)OCC2=CC=CC=C2

Technology Process of (3S)-3-Methyl-1-(phenylmethoxy)-2,5-pyrrolidinedione

There total 4 articles about (3S)-3-Methyl-1-(phenylmethoxy)-2,5-pyrrolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 622-33-3
N-benzyloxyamine

: 6973-20-2
(S)-methylsuccinic anhydride

: 182007-76-7
(4S)-methyl-N-O-benzyl-pyrrolidine-2,5-dione

Guidance literature:: With 1,1'-carbonyldiimidazole;
DOI:10.1039/cc9960001797

Reference yield: 89.0%

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 6973-20-2
(S)-methylsuccinic anhydride

: 182007-76-7
(4S)-methyl-N-O-benzyl-pyrrolidine-2,5-dione

Guidance literature:: O-benzylhydoxylamine hydrochloride; (S)-methylsuccinic anhydride; With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 2h; Reflux; Inert atmosphere;
DOI:10.1021/jm501082n

Reference yield:

: 2174-58-5
L-malic acid

: 182007-76-7
(4S)-methyl-N-O-benzyl-pyrrolidine-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: acetyl chloride / 60 °C

2: N,N'-carbonyldiimidazole / CH₂Cl₂ / 0 - 45 °C

With acetyl chloride; 1,1'-carbonyldiimidazole; In dichloromethane;
DOI:10.1016/j.bmcl.2004.12.002