L-Histidine, methyl ester, monohydrochloride

Base Information

• Chemical Name: L-Histidine, methyl ester, monohydrochloride
• CAS No.: 18684-16-7
• Molecular Formula: C7H11N3O2.ClH
• Molecular Weight: 205.644
• Mol file: 18684-16-7.mol

Synonyms:(L)-histidine methyl ester dihydrochloride;L-histidine methyl ester dihydrochloride salt;H-L-His-OMe dihydrochloride;H-His-OMe dihydrochloride;methyl L-histidinate dihydrochloride;L-(+)-histidine methyl ester dihydrochloride;

Chemical Property of L-Histidine, methyl ester, monohydrochloride

Chemical Property:

• PSA: 81.00000
• LogP: 0.95480

Purity/Quality:

97% ^*data from raw suppliers

L-Histidine Methyl Ester Hydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Histidine, methyl ester, monohydrochloride

There total 22 articles about L-Histidine, methyl ester, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

L-histidine monohydrochloride (645-35-2) + trimethyl orthoformate (149-73-5) → l-histidine methyl ester dihydrochloride (4467-54-3,5619-10-3,7389-87-9,18684-16-7,22888-60-4,32381-17-2,92742-29-5,100009-20-9)

Guidance literature:

With thionyl chloride; In methanol; at 0 ℃; for 16h; Inert atmosphere; Reflux;

DOI:10.1002/chir.22056

Reference yield: 100.0%

methanol (67-56-1) + L-histidine (71-00-1,26062-48-6,90081-11-1) → l-histidine methyl ester dihydrochloride (4467-54-3,5619-10-3,7389-87-9,18684-16-7,22888-60-4,32381-17-2,92742-29-5,100009-20-9)

Guidance literature:

With acetyl chloride; for 24h;

DOI:10.1002/chem.200601420

Reference yield: 100.0%

D-histidine monohydrochloride (6341-24-8) + trimethyl orthoformate (149-73-5) → (R)-histidine methyl ester dihydrochloride (4467-54-3,5619-10-3,7389-87-9,18684-16-7,22888-60-4,32381-17-2,92742-29-5,100009-20-9)

Guidance literature:

With thionyl chloride; In methanol; at 0 ℃; for 16h; Inert atmosphere; Reflux;

DOI:10.1002/chir.22056

upstream raw materials:

methanol

L-histidine

L-histidine monohydrochloride

L-histidine

Downstream raw materials:

Z-glycyl-glycyl-L-histidine methyl ester

Dodecanoic acid (2S,3R,4S,5S,6R)-4,5-bis-dodecanoyloxy-6-dodecanoyloxymethyl-2-{2-[(S)-2-(1H-imidazol-4-yl)-1-methoxycarbonyl-ethylamino]-cyclohexylsulfanyl}-tetrahydro-pyran-3-yl ester

Dodecanoic acid (2S,3R,4S,5S,6R)-4,5-bis-dodecanoyloxy-6-dodecanoyloxymethyl-2-{3-[(S)-2-(1H-imidazol-4-yl)-1-methoxycarbonyl-ethylamino]-cyclohexylsulfanyl}-tetrahydro-pyran-3-yl ester

Dodecanoic acid (2S,3R,4S,5S,6R)-4,5-bis-dodecanoyloxy-6-dodecanoyloxymethyl-2-{5-[(S)-2-(1H-imidazol-4-yl)-1-methoxycarbonyl-ethylamino]-2,2-dimethyl-cyclohexylsulfanyl}-tetrahydro-pyran-3-yl ester