Benzenethiol, 4-(4-pyridinyl)-

Base Information

• Chemical Name: Benzenethiol, 4-(4-pyridinyl)-
• CAS No.: 188358-98-7
• Molecular Formula: C11H9NS
• Molecular Weight: 187.265
• Mol file: 188358-98-7.mol

Synonyms:

Chemical Property of Benzenethiol, 4-(4-pyridinyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenethiol, 4-(4-pyridinyl)-

There total 5 articles about Benzenethiol, 4-(4-pyridinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-(4-(methylthio)phenyl)pyridine (4373-71-1) → 4-(pyridin-4-yl)benzenethiol (188358-98-7)

Guidance literature:

With sodium tert-butyl thiolate; In N,N-dimethyl-formamide; at 170 ℃; for 48h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.10.097

Reference yield: 32.0%

4-(4-chlorophenyl)pyridine (5957-96-0) + thiourea (17356-08-0) → 4-(pyridin-4-yl)benzenethiol (188358-98-7)

Guidance literature:

With 4,4'-bipyridine; potassium tert-butylate; In ammonia; at -40 ℃; electrolysis;

DOI:10.1016/S0040-4039(96)02366-0

Reference yield:

(4-thiomethoxyphenyl)boronic acid (98546-51-1) → 4-(pyridin-4-yl)benzenethiol (188358-98-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / KOH; Bu₄NBr / tetrakis(triphenylphosphine)palladium / 1,2-dimethoxy-ethane; H₂O / 48 h / 80 °C

2: 81.1 percent / t-BuSNa / dimethylformamide / 5 h / Heating

With potassium hydroxide; tetrabutylammomium bromide; sodium tert-butyl thiolate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 1: Suzuki coupling;

DOI:10.1016/j.bmc.2006.09.058

upstream raw materials:

4-(4-chlorophenyl)pyridine

thiourea

4-(4-(methylthio)phenyl)pyridine

(4-bromophenyl)thioanisole

Downstream raw materials:

4-(4-pyridyl)phenyl disulfide

4-pyridylphenyl methanethiosulfonate

Refernces

• 1、 Bartucci, Matthew A.,Wierzbicki, Patrycja M.,Gwengo, Chengeto,Shajan, Sunny,Hussain, Syed H.,Ciszek, Jacob W.. "Synthesis of dihydroindolizines for potential photoinduced work function alteration". supporting information; experimental part. p. 6839 - 6842. Retrieved 2011/03/18.
• 2、 Combellas,Dellerue,Mathey,Thiebault. "Nucleophilic properties of thiourea towards aromatic halides". . p. 539 - 542. Retrieved 2007/10/03.