4-(4-CHLORO-PHENYL)-PYRIDINE

Base Information

• Chemical Name: 4-(4-CHLORO-PHENYL)-PYRIDINE
• CAS No.: 5957-96-0
• Molecular Formula: C11H8ClN
• Molecular Weight: 189.644
• Hs Code.: 2933399090
• Mol file: 5957-96-0.mol

Synonyms:Pyridine,4-(p-chlorophenyl)- (7CI,8CI);4-(4-Chlorophenyl)pyridine;NSC 193507;

Chemical Property of 4-(4-CHLORO-PHENYL)-PYRIDINE

Chemical Property:

• Vapor Pressure: 0.00236mmHg at 25°C
• Melting Point: 108-109 °C
• Refractive Index: 1.588
• Boiling Point: 297.6 °C at 760 mmHg
• PKA: 5.36±0.10(Predicted)
• Flash Point: 161.9 °C
• PSA: 12.89000
• Density: 1.186 g/cm³
• LogP: 3.40200
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

4-(4-Chlorophenyl)pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-CHLORO-PHENYL)-PYRIDINE

There total 25 articles about 4-(4-CHLORO-PHENYL)-PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-Chlorophenylboronic acid (1679-18-1) + 4-bromopyridine hydrobromide salt (74129-11-6) → 4-(4-chlorophenyl)pyridine (5957-96-0)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; water; at 110 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.5b00215

Reference yield: 99.0%

1-Chloro-4-iodobenzene (637-87-6) + 4-pyridylboronic acid (1692-15-5) → 4-(4-chlorophenyl)pyridine (5957-96-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; N,N-dimethyl-formamide; at 85 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.0c03836

Reference yield: 90.0%

4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride (51304-61-1) → 4-(4-chlorophenyl)pyridine (5957-96-0)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 45 ℃; for 48h;

DOI:10.1021/ja0400382

upstream raw materials:

pyridine

4-chlorophenyldiazonium salt

bis(4-chlorobenzoyl)peroxide

p-chlorobenzenediazonium tetrafluoroborate

Downstream raw materials:

4-(pyridin-4-yl)benzenethiol

4-(4-dimethylaminophenyl)pyridine

C₁₂H₁₁ClN⁽¹⁺⁾*I^(1-)

Refernces

• 1、 Bartolomeu, Aloisio De A.,Brocksom, Timothy J.,De Oliveira, Kleber T.,No?l, Timothy,Silva, Rodrigo C.. "Photoarylation of Pyridines Using Aryldiazonium Salts and Visible Light: An EDA Approach". . . Retrieved 2019/08/26.
• 2、 Hofmann, Josefa,Gans, Eva,Clark, Timothy,Heinrich, Markus R.. "Radical Arylation of Anilines and Pyrroles via Aryldiazotates". . p. 9647 - 9656. Retrieved 2017/07/22.