5957-96-0

Basic information

• Product Name: 4-(4-CHLORO-PHENYL)-PYRIDINE
• Synonyms: 4-(4-CHLORO-PHENYL)-PYRIDINE
• CAS NO: 5957-96-0
• Molecular Formula: C₁₁H₈ClN
• Molecular Weight: 189.64
• Mol File: 5957-96-0.mol
• Article Data: 23

Chemical Properties

• Melting Point: 108-109 °C
• Boiling Point: 297.6 °C at 760 mmHg
• Flash Point: 161.9 °C
• Appearance: /
• Density: 1.186 g/cm³
• Vapor Pressure: 0.00236mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 5.36±0.10(Predicted)
• CAS DataBase Reference: 4-(4-CHLORO-PHENYL)-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-CHLORO-PHENYL)-PYRIDINE(5957-96-0)
• EPA Substance Registry System: 4-(4-CHLORO-PHENYL)-PYRIDINE(5957-96-0)

Safety Data

• Hazardous Substances Data: 5957-96-0(Hazardous Substances Data)

Usage

General Description

4-(4-chloro-phenyl)-pyridine is a chemical compound with the molecular formula C11H8ClN. It belongs to the class of pyridine derivatives and is characterized by a chloro group attached to the fourth position of the phenyl ring in the pyridine structure. 4-(4-CHLORO-PHENYL)-PYRIDINE has applications in the pharmaceutical and agrochemical industries, where it can be used as an intermediate in the synthesis of various pharmaceuticals and pesticides. It is also used in research and development as a building block for the creation of new chemical compounds. Additionally, 4-(4-chloro-phenyl)-pyridine has potential applications in material science and organic synthesis due to its unique structure and reactivity.

InChI:InChI=1/C11H8ClN/c12-11-3-1-9(2-4-11)10-5-7-13-8-6-10/h1-8H

Upstream product

• 110-86-1 pyridine 
• 94-17-7 bis(4-chlorobenzoyl)peroxide 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 106-47-8 4-chloro-aniline 
• 106-39-8 bromochlorobenzene 
• 7379-35-3 4-chlorpyridine hydrochloride 
• 30005-58-4 4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine 
• 51304-61-1 4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride 
• 1692-15-5 4-pyridylboronic acid 
• 1679-18-1 4-Chlorophenylboronic acid 
• 74129-11-6 4-bromopyridine hydrobromide salt 
• 637-87-6 1-Chloro-4-iodobenzene 
• 628-13-7 pyridine hydrochloride 
• 873-77-8 (4-chlorphenyl)magnesium bromide 

Downstream Products

• 92929-25-4 4-(4-chlorophenyl)pyridine 1-oxide 
• 342889-58-1 4-[4-(6-methoxynaphth-2-yl)phenyl]pyridine 
• 1137-80-0 4-(4-dimethylaminophenyl)pyridine 
• 118931-21-8 C₁₂H₁₁ClN⁽¹⁺⁾*I^(1-) 
• 188358-98-7 4-(pyridin-4-yl)benzenethiol 

Relevant articles and documents

Nickel-Catalyzed Amination of Aryl Chlorides with Amides

A nickel-catalyzed amination of aryl chlorides with diverse amides via C-N bond cleavage has been realized under mild conditions. A broad substrate scope with excellent functional group tolerance at a low catalyst loading makes the protocol powerful for synthesizing various aromatic amines. The aryl chlorides could selectively couple to the amino fragments rather than the carbonyl moieties of amides. Our protocol complements the conventional amination of aryl chlorides and expands the usage of inactive amides.

Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

A sustainable MAO-N biocatalyzed process for the synthesis of pyridines from aliphatic tetrahydropyridines (THP) has been developed. Pyridine compounds were synthesized under mild reaction conditions and with high conversion, exploiting MAO-N whole cells as aromatizing biocatalysts. The kinetic profile of the whole cell biocatalytic transformation was finally investigated via in situ 19F NMR.

Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment

Recent studies in adipose tissue, pancreas, muscle, and macrophages suggest that MAP4K4, a serine/threonine protein kinase may be a viable target for antidiabetic drugs. As part of the evaluation of MAP4K4 as a novel antidiabetic target, a tool compound,