Methyl 4-chloro-2-Methyl-5-nitrobenzoate

Base Information

• Chemical Name: Methyl 4-chloro-2-Methyl-5-nitrobenzoate
• CAS No.: 190367-56-7
• Molecular Formula: C9H8ClNO4
• Molecular Weight: 229.62
• Mol file: 190367-56-7.mol

Synonyms:

Chemical Property of Methyl 4-chloro-2-Methyl-5-nitrobenzoate

Chemical Property:

• Boiling Point: 335.8±37.0 °C(Predicted)
• Density: 1.371±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Methyl4-Chloro-2-methyl-5-nitrobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 4-chloro-2-Methyl-5-nitrobenzoate

There total 5 articles about Methyl 4-chloro-2-Methyl-5-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.2%

methanol (67-56-1) + 4-chloro-2-methyl-5-nitrobenzoic acid (476660-41-0) → methyl 4-chloro-2-methyl-5-nitrobenzoate (190367-56-7)

Guidance literature:

With hydrogenchloride; In water; at 80 ℃;

Reference yield:

methanol (67-56-1) + 4-chloro-2-methyl-3-nitro-benzoic acid (950915-10-3) + 4-chloro-2-methyl-5-nitrobenzoic acid (476660-41-0) → methyl 4-chloro-2-methyl-5-nitrobenzoate (190367-56-7) + 4-chloro-2-methyl-3-nitrobenzoic acid methyl ester (190367-57-8)

Guidance literature:

With hydrogenchloride; at 0 ℃; for 1h;

Reference yield:

methanol (67-56-1) + 4-chloro-2-methylbenzoic acid (7499-07-2) → methyl 4-chloro-2-methyl-5-nitrobenzoate (190367-56-7) + 4-chloro-2-methyl-3-nitrobenzoic acid methyl ester (190367-57-8)

Guidance literature:

With hydrogenchloride; nitric acid; Yield given. Multistep reaction. Yields of byproduct given; 1.) 0 - 5 deg C, 1 h, 2.) reflux, 6 h;

DOI:10.1021/jm960768n

upstream raw materials:

methanol

4-chloro-2-methylbenzoic acid

para-chlorobenzoic acid

4-chloro-2-methyl-3-nitro-benzoic acid

Downstream raw materials:

methyl 2-methyl-4-(methylamino)-5-nitrobenzoate

4-cyclohexylamino-2-methyl-5-nitrobenzoic acid methyl ester

4-cyclohexylamino-2-methyl-3-nitrobenzoic acid methyl ester

Refernces

• 1、 -. "BENZOIMIDAZOLE DERIVATIVES AS PAD4 INHIBITORS". . . Retrieved 2016/12/07.
• 2、 Baumgarth, Manfred,Beier, Norbert,Gericke, Rolf. "(2-methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors". . p. 2017 - 2034. Retrieved 2007/10/03.