4-Chloro-4'-methyl-1,1'-biphenyl

Base Information

• Chemical Name: 4-Chloro-4'-methyl-1,1'-biphenyl
• CAS No.: 19482-11-2
• Molecular Formula: C13H11Cl
• Molecular Weight: 202.683
• Hs Code.: 2903999090
• DSSTox Substance ID: DTXSID90374000
• Nikkaji Number: J1.136.532I
• Wikidata: Q82162436
• Mol file: 19482-11-2.mol

Synonyms:4-chloro-4'-methyl-1,1'-biphenyl;19482-11-2;1-chloro-4-(4-methylphenyl)benzene;4-chloro-4'-methylbiphenyl;4-Chloro-4/'-methyl-1,1/'-biphenyl;4'-chloro-4-methylbiphenyl;SCHEMBL425166;Biphenyl, 4-chloro-4'-methyl-;DTXSID90374000;XYOKCUNCQZYSPK-UHFFFAOYSA-N;MFCD06201392;AKOS004116239;AS-60858;BB 0223396;CS-0153069;C73702;J-515033;4-chloro-4 inverted exclamation mark(R)-methylbiphenyl

Chemical Property of 4-Chloro-4'-methyl-1,1'-biphenyl

Chemical Property:

• PSA: 0.00000
• LogP: 4.31540
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 1
• Exact Mass: 202.0549280
• Heavy Atom Count: 14
• Complexity: 162

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloro-4'-methyl-1,1'-biphenyl 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=CC=C(C=C2)Cl

Technology Process of 4-Chloro-4'-methyl-1,1'-biphenyl

There total 75 articles about 4-Chloro-4'-methyl-1,1'-biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-tolyl iodide (624-31-7) + 4-Chlorophenylboronic acid (1679-18-1) → 4-chloro-4'-methylbiphenyl (19482-11-2)

Guidance literature:

With potassium carbonate; [PS-PEG-adppp-Pd(η³-C3H5)]Cl; In water; at 50 ℃; for 12h;

DOI:10.1021/ol0264298

Reference yield: 99.0%

para-bromotoluene (106-38-7) + 4-Chlorophenylboronic acid (1679-18-1) → 4-chloro-4'-methylbiphenyl (19482-11-2)

Guidance literature:

With palladium diacetate; N,N'-dicyclohexylethylenediimine; caesium carbonate; In 1,4-dioxane; at 80 ℃; for 6h;

DOI:10.1021/ol015676t

Reference yield: 98.0%

1-Chloro-4-iodobenzene (637-87-6) + 4-methyl phenylboronic acid → 4-chloro-4'-methylbiphenyl (19482-11-2)

Guidance literature:

With potassium carbonate; In ethanol; water; at 70 ℃; for 1h; Under air;

DOI:10.1016/j.tetlet.2011.01.092

upstream raw materials:

4-chloro-aniline

p-methylbenzenediazonium chloride

chlorobenzene

1,6-bis-(4-chlorophenyl)-3,4-diacetyl-1,5-hexazadiene

Downstream raw materials:

4-(4-methylphenyl)aniline

p-(p-tolyl)benzonitrile

[(η6-1-chloro-4'-methylbiphenyl)Cr(CO)3]

4-(bromomethyl)-4'-chloro-1,1'-biphenyl

Refernces

• 1、 Gogoi, Ankur,Chutia, Sankar Jyoti,Gogoi, Pradip K.,Bora, Utpal. "A highly efficient heterogeneous montmorillonite K-10-supported palladium catalyst for Suzuki-Miyaura cross-coupling reaction in aqueous medium". . p. 839 - 844. Retrieved 2014.
• 2、 Wang, Jiayi,Song, Gonghua,Peng, Yanqing. "Reusable Pd nanoparticles immobilized on functional ionic liquid co-polymerized with styrene for Suzuki reactions in water-ethanol solution". . p. 1477 - 1480. Retrieved 2011.
• 3、 Gund, Sitaram Haribhau,Balsane, Kishor Eknath,Nagarkar, Jayashree Milind. "Desulfinylative Pd-catalyzed coupling reaction of arenediazonium salt with aryl sulfinates to give unsymmetrical biaryls". . p. 2936 - 2939. Retrieved 2017.
• 4、 Rafiee, Fatemeh,Hosseini, S. Azam. "Pd nanoparticles immobilized on the magnetic silica–chitosan nanocomposite (NiFe2O4@SiO2@CS-Pd NPs) promoted the biaryl synthesis". . p. 1993 - 2001. Retrieved 2019.
• 5、 Raza, Faizan,Yim, Dabin,Park, Jung Hyun,Kim, Hye-In,Jeon, Su-Ji,Kim, Jong-Ho. "Structuring Pd Nanoparticles on 2H-WS2 Nanosheets Induces Excellent Photocatalytic Activity for Cross-Coupling Reactions under Visible Light". . p. 14767 - 14774. Retrieved 2017.
• 6、 Wan, Jie-Ping,Wang, Chunping,Zhou, Rihui,Liu, Yunyun. "Sustainable H2O/ethyl lactate system for ligand-free Suzuki-Miyaura reaction". . p. 8789 - 8792. Retrieved 2012.
• 7、 Sun, Yunqiang,Li, Xiaoyan,Sun, Hongjian. "Arylation of non-activated C-Cl bond with Grignard reagents catalyzed by pincer [PCP]-nickel complexes". . p. 95 - 97. Retrieved 2014.
• 8、 Bárta, Ond?ej,Císa?ová, Ivana,?těpni?ka, Petr. "Synthesis, Palladium(II) Complexes, and Catalytic Use of a Phosphanylferrocene Ligand Bearing a Guanidinium Pendant". . p. 489 - 495. Retrieved 2017.
• 9、 Azizollahi, Hamid,Eshghi, Hossein,García-López, José-Antonio. "Fe3O4-SAHPG-Pd0 nanoparticles: A ligand-free and low Pd loading quasiheterogeneous catalyst active for mild Suzuki–Miyaura coupling and C-H activation of pyrimidine cores". . . Retrieved 2020/09/17.
• 10、 Goetz, Roland,Hashmi, A. Stephen K.,Orecchia, Patrizio,Petkova, Desislava Slavcheva,Rominger, Frank,Schaub, Thomas. "Pd-Catalysed Suzuki-Miyaura cross-coupling of aryl chlorides at low catalyst loadings in water for the synthesis of industrially important fungicides". supporting information. p. 8169 - 8180. Retrieved 2021/11/01.