11-Methoxy-7-methyl-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)be nzodiazepin-5-one

Base Information

Chemical Name:11-Methoxy-7-methyl-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)be nzodiazepin-5-one
CAS No.:116564-73-9
Molecular Formula:C14H18N2O2
Molecular Weight:246.3
Hs Code.:
Mol file:116564-73-9.mol

Synonyms:11-Methoxy-7-methyl-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)be nzodiazepin-5-one

Suppliers and Price of 11-Methoxy-7-methyl-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)be nzodiazepin-5-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
11-METHOXY-7-METHYL-1,2,3,10,11,11A-HEXAHYDRO-5H-PYRROLO(2,1-C)(1,4)BE NZODIAZEPIN-5-ONE 95.00%
5MG
$ 502.56

Total 1 raw suppliers

Chemical Property of 11-Methoxy-7-methyl-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)be nzodiazepin-5-one

Chemical Property:

Vapor Pressure:4.8E-08mmHg at 25°C
Boiling Point:443°Cat760mmHg
PKA:2.04±0.40(Predicted)
Flash Point:221.7°C
PSA：41.57000
Density:1.22g/cm³
LogP:2.07350

Purity/Quality:: 11-METHOXY-7-METHYL-1,2,3,10,11,11A-HEXAHYDRO-5H-PYRROLO(2,1-C)(1,4)BE NZODIAZEPIN-5-ONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 11-Methoxy-7-methyl-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)be nzodiazepin-5-one

There total 6 articles about 11-Methoxy-7-methyl-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)be nzodiazepin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100230-83-9
N-(5-methyl-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde

: 100231-12-7
1,2,3,11a-tetrahydro-7-methyl-5H-pyrrolo<2,1-c><1,4>benzodiazepin-5-one

: 105089-74-5
11-Hydroxy-7-methyl-1,2,3,10,11,11a-hexahydro-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one

: 100230-91-9
7-Methyl-1,2,3,10,11,11a-hexahydro-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one

: 116564-73-9
7-methyl-11-methoxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo<2,1-c><1,4>benzodiazepin-5-one

Guidance literature:: With hydrogen; palladium on barium sulfate; In methanol; for 0.25h; under 760 Torr;
DOI:10.1021/jo00355a022

Reference yield:

: 67-56-1
methanol

: 100230-83-9
N-(5-methyl-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde

: 100231-12-7
1,2,3,11a-tetrahydro-7-methyl-5H-pyrrolo<2,1-c><1,4>benzodiazepin-5-one

: 105089-74-5
11-Hydroxy-7-methyl-1,2,3,10,11,11a-hexahydro-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one

: 100230-91-9
7-Methyl-1,2,3,10,11,11a-hexahydro-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one

: 116564-73-9
7-methyl-11-methoxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo<2,1-c><1,4>benzodiazepin-5-one

Guidance literature:: With hydrogen; palladium on barium sulfate; In methanol; for 0.25h; under 760 Torr; Title compound not separated from byproducts;
DOI:10.1021/jo00355a022

Reference yield:

: 3113-72-2
5-methyl-2-nitrobenzoic acid

: 116564-73-9
7-methyl-11-methoxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo<2,1-c><1,4>benzodiazepin-5-one

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl chloride, DMF / benzene / 3 h

2: Et₃N / tetrahydrofuran; H₂O / 1 h / Ambient temperature

3: oxalyl chloride, DMF / benzene / 3 h

4: triphenylphosphine, bis(triphenylphosphine) copper borohydride / acetone / 0.5 h / 0 °C

5: H₂ / 5percent Pd-BaSO₄ / methanol / 0.25 h / 760 Torr

With oxalyl dichloride; bis(triphenylphosphine) copper borohydride; hydrogen; triethylamine; N,N-dimethyl-formamide; triphenylphosphine; palladium on barium sulfate; In tetrahydrofuran; methanol; water; acetone; benzene;
DOI:10.1021/jo00355a022